2. Sub-complex Diversity and Recruitment

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[question]

[answer]**.

How many distinct sub-complex assemblies of BAF exist in mammals

Three.

What are the three distinct BAF sub-complex assemblies in mammals

cBAF (canonical), PBAF, and ncBAF (non-canonical).

Do the three BAF sub-complexes have the same genomic targets

No, each has specific genomic targets.

Where is cBAF specifically enriched

At active and primed enhancers.

Which subunit in cBAF acts as a "reader" of the H3K4me1 mark

DPF2.

Which BAF sub-complexes show a stronger preference for promoters

ncBAF and PBAF.

Which subunit is critical for targeting ncBAF to specific regulatory regions

BRD9.

Which subunit is critical for targeting PBAF to specific regulatory regions

BR