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Whole blood contains
All cellular formations, antibodies, and clotting factors
Packed red cells contain
Only RBCs
Fresh frozen plasma contains
Antibodies and clotting factors
Platelet units contain
Minimal amounts of RBCs, antibodies, clotting factors, and platelets
Cryoprecipitate contains
Clotting factors only
ABO whole blood compatibility
Type specific only
Packed cell compatibility
O to everything, A and B to AB, O gets nothing
Plasma product availability
AB to everything, A and B to AB, AB receives nothing
Blood type makes antibodies against
The type they donāt like
Antibodies in plasma
A: anti-B
B: Anti-A
AB: none
O: anti-a and anti-b
Antigens on red blood cell
a: a
b: b
AB: a and b
O: none
Blood bank functions
Facility that collects, stores, processes, and distribution for blood products for transfusion
Regulatory orgs for blood banks
FDA, CMS, State health depts, and OSHA
Accreditation agencies for blood banks
AABB, JCO, CAP, FACT, NMDP, and WMDA
Regulations under FD and C act, and PHS
Blood and its components are drugs, obtain bio licenses to ship in interstate commerce, mandate adherence to cGMP, follows unit from collection to transfusion
FDA regulations:
CBER: inspections, medical devices used
ORA: responsibility over all field operations, inspections, and investigations of blood and device manufacturers
FDA inspections
Pre-license/ approval
Routine inspection
āFor causeā (serious injury)
Class I recalls
Reasonable probability of serious/ fatal effects
Class II recall
May cause temporary adverse effects or remotely serious problems
Class III recalls
Not likely to cause adverse consequences (most common)
AABB checklist updated
Every 2 years
AABB and CAP accredited labs have physical inspections every
2 years
Main difference between blood bank w a collection facility and those without š¤Ø
Ones w /collection units collect their own supply of blood units
Functions of a donor center
Recruitment, prep and storage, processing (testing) , labeling, HIV database, paternity testing, and rare donor recruitment
Function of a reference blood bank lab
Problem solving: ABO discrepancies, RH discrepancies, antibody ID, molecular genotyping, DAT, warm and cold autoantibodies, transfusion reaction workup
Positive DAT indicates:
Immune reaction to drug or disease
Current or delayed immunocompatibility
Warm and cold autoantibodies
Cause positive DAT and can mask alloantibodies
Transfusion reaction workup
Investigate cause of symptoms following a transfusion reaction