adv biochem nucleutide synthesis

part 3

Allopurinol, an effective drug to treat gout works as a 

competitive inhibitor

A mutation in which of the following enzyme may lead to Lesch-Nyhan syndrome

Hypoxanthine-Guanine phosphoribosyl transferase 

A cell that is unable to synthesize or obtain methylene tetrahydrofolate would probably be deficient in the biosynthesis of

TMP

All of the following is true for dihydrofolate reductase except.

it is inhibitedCon NOT produce uric acid  by fluorouracil (FdUMP)

Catabolism (breakdown) of UDP-glucose molecule

Can NOT produce uric acid

How allopurinol lowers the gout-related pain?

inhibits the enzyme xanthine oxidase so less uric acid is made.

Which nucleotide upregulates the reduction of ADP to dADP by ribonucleotide reductase

dGTP

One nucleoside diphosphate kinase can convert 
(a) CDP → CTP  
(b) dCDP → dCTP  
(c) dGDP → dGTP

a, b, and c

Which of the following nucleotide pairs can be made by the same monophosphate nucleoside kinase?
(a) dADP (b) dCDP (c) GDP  (d) ATP  (e) dGDP

c and e

Which is true for the formation of CTP from UTP

in the formation of UTP from CTP an amino group is added 

The rate limiting enzyme of purine biosynthesis is catalyzed by the enzyme:

glutamine-PRPP amidotransferase

The nitrogen atom(s) of purine bases are derived from all of the following amino acids EXCEPT:

Asparagine

When the formation of AMP from IMP occurs, which particular high energy molecule (NTP) is used? 

GTP

PRPP is the source of ribose in nucleotide synthesis. How many phosphate groups are in PRPP? 

3

There are five carbons in the general structure of purine ring. Two of those carbons are contributed by amino acid glycine  the other three come from:

CO2 and Formate