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Q: What organs make up the urinary system?
A: Kidneys, ureters, urinary bladder, urethra.
Q: Where are the kidneys located?
posterior abdominal wall, between T12–L3 vertebrae.
Q: What are the main functions of the kidneys?
A: Filter blood, regulate water/electrolytes, acid-base balance, blood pressure, and hormone production (erythropoietin, calcitriol).
Q: What are the major nitrogenous wastes?
A: Urea, uric acid, creatinine.
Q: Where do nitrogenous wastes come from?
Urea → protein/amino acid breakdown
Uric acid → nucleic acid metabolism
Creatinine → muscle metabolism (creatine phosphate)
Q: What is excretion?
A: Removal of metabolic wastes from the body.
Q: Which systems are involved in excretion?
A: Urinary, respiratory, integumentary, digestive systems.
Q: What is the general shape of the kidney?
A: Bean-shaped, reddish-brown organ.
Q: What are the external features of the kidney?
A: Renal capsule, renal hilum, renal cortex, renal medulla.
Q: What are internal kidney structures?
A: Renal pyramids, calyces (minor/major), renal pelvis.
Q: Trace blood flow through the kidney.
A: Renal artery → segmental → interlobar → arcuate → cortical radiate → afferent arteriole → glomerulus → efferent arteriole → peritubular capillaries/vasa recta → veins → renal vein.
Q: Trace filtrate flow through the nephron.
A: Glomerulus → Bowman’s capsule → PCT → loop of Henle → DCT → collecting duct → papillary duct → minor calyx.
Q: What is the nerve supply to the kidney?
A: Renal plexus (sympathetic nerves; regulates blood flow and filtration rate).
Q: What is glomerular filtration?
A: Movement of plasma from glomerular capillaries into Bowman’s capsule.
Q: What structure enables filtration?
A: Glomerulus (fenestrated capillaries + filtration membrane).
Q: What forces promote filtration?
A: Glomerular blood pressure.
Q: What forces oppose filtration?
A: Blood colloid osmotic pressure and capsular hydrostatic pressure.
Q: What is net filtration pressure (NFP)?
A: NFP = (glomerular blood pressure) − (capsular pressure + osmotic pressure)
Q: How is filtration regulated by the nervous system?
A: Sympathetic activation decreases GFR by constricting afferent arterioles.
Q: How do hormones regulate filtration?
Angiotensin II ↓ or maintains GFR
ANP ↑ GFR
Q: What is tubular reabsorption?
A: Movement of substances from tubular fluid back into blood.
Q: What is reabsorbed in the PCT?
A: Glucose, amino acids, Na⁺, water, bicarbonate.
Q: What is tubular secretion?
A: Movement of substances from blood into tubule.
Q: What is secreted by the tubules?
A: H⁺, K⁺, creatinine, drugs, toxins.
Q: How is water excretion regulated?
A: Through aquaporins controlled mainly by ADH.
Q: What does ADH do?
A: Increases water reabsorption in collecting ducts → concentrates urine.
Q: What does the collecting duct regulate?
A: Final urine volume and concentration.
Q: What maintains the medullary osmotic gradient?
A: Countercurrent multiplication in loop of Henle + vasa recta.
Q: What is normal urine made of?
A: Water (~95%), urea, salts, creatinine, uric acid.
Q: What are abnormal urine components?
A: Glucose, proteins, blood, ketones.
Q: What is a key measure of kidney function?
A: Glomerular filtration rate (GFR).
Q: What is the function of ureters?
A: Transport urine from kidneys to bladder via peristalsis.
Q: What are the layers of the urinary bladder?
A: Mucosa, detrusor muscle, serosa/adventitia.
Q: What is the function of the urinary bladder?
A: Temporary urine storage.
Q: What controls urination (micturition)?
A: Parasympathetic nervous system + sphincters.
Q: What are the urethral sphincters?
A: Internal (involuntary) and external (voluntary).
Q: Difference between male and female urethra?
A: Male: longer, carries urine + semen. Female: shorter, only urine.