LEOKOTRINE MODIFIERS

Flashcards covering key terms and concepts related to Leukotriene Modifiers, including mechanisms of action, pharmacokinetics, side effects, and contraindications.

Leukotrienes

Inflammatory mediators produced by eosinophils and mast cells that can lead to bronchospasm, airway hyperresponsiveness, and vascular leakage.

Montelukast

A Leukotriene Receptor Agonist that inhibits the cysteinyl leukotriene receptor, blocking the action of LTD4.

Zileuton

A 5-Lipoxygenase Pathway Inhibitor that inhibits the enzyme responsible for the formation of leukotrienes from arachidonic acid.

Pharmacokinetics

The study of how drugs are absorbed, metabolized, and excreted, relevant to both Montelukast and Zileuton.

CYP3A4

An enzyme that metabolizes Montelukast and Zileuton.

Neuropsychiatric events

Side effects associated with Leukotriene Modifiers, including irritability, agitation, and depression.

PKU

Phenylketonuria, a condition that contraindicates the use of Montelukast chewable tablets due to phenylalanine content.

Contraindications

Conditions under which a drug should not be used; for instance, severe liver disease for Leukotriene Receptor Agonists.