Peripheral Neuropathy Treatment

treat underlying disease

alleviate symptoms

What are the two main components to treat polyneuropathy?

adequate sugar control

avoid triggering toxin

treat with supplementation

How would we treat the underlying disorder of DM, ETOH, drugs, vitamin B12 for poly neuropathy?

anticonvulsant medications

antidepressants

medication for breakthrough pain

What medications can be used for symptom relief in polyneuropathy?

gabapentin, pregablin

What anticonvulsant meds can be used for polyneuropathy?

TCAs like amitriptyline, nortriptyline

SNRIs like duloxetine

What antidepressant meds can be used for polyneuropathy treatment?

NSAIDs, tramadol or low dose narcotics

What meds can be used for breakthrough pain of polyneuropathy?

gabapentin

anti-convulsant

modulates release of excitatory neurotransmitters that can play a role in nociception

drowsiness, dizziness

Side effects of gabapentin?

potential for abuse, potentiation of opioid high

Caution of gabapentin?

pregabalin

anti-convulsant

binds to voltage gated calcium channels and inhibits effects of excitatory neurotransmitters

drowsiness, dizziness, peripheral edema

Side effects of pregabalin?

potential for abuse, potentiation of opioid high

caution for pregabalin?