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lesion
wound or injury of the brain
experimental ablation
the removal/injury of a portion of the brain of a lab animal
CT scan
x-rays produce a 2D image of the brain in medium resolution
adenosine
neuromodulator that is thought to promote sleep
increased adenosine
inhibits neural activity, encourages sleep, sleep wake cycle replenishes glycogen
caffeine
an antagonist that blocks adenosine receptors in the brain
neurotransmitters that help you stay awake
acetylcholine, norepinephrine, serotonin, histamine
orexin
originate in lateral hypothalamus, sends excitatory messages across brain to keep you awake
sleep-wake flip flop circuit
arousal neurotransmitters and sleep neurons in ventrolateral preoptic area (vlPOA) send messages to each other to induce sleep or wakefulness
acetylcholine
high levels during waking and REM stages
raphe nuclei
serotonin is found in the ____ of the midbrain and the hindbrain
locus coeruleus
norepinephrine is found in here
decreases, increases
as glycogen _____, adenosine _____
sleep neurons
found in the ventrolateral preoptic area and secrete GABA
long-term potentiation
neurons that fire together wire together
increase in the excitability of a neuron to a particular synaptic input caused by repeated high-frequency activity of that input
LTP occurs
presynaptic and postsynaptic cells are depolarised at the same time
NMDA receptors
open when depolarized by a strong synapse, allowing calcium ions to enter the cell. beginning of LTP
calcium ions
allows AMPA receptors to attach to dendrites and strengthen the synapses, leading to more excitatory postsynaptic potentials
AMPA receptors
control sodium ion channels, increases excitatory PSPs
Broca’s area
speech production
Primary auditory cortex
in temporal lobe, processes sensory info from auditory system
Wernicke’s area
word recognition, not comprehension
Posterior language area
interface between word recognition and what it actually means
Arcuate Fasciculus
connects Wernicke’s and Broca’s area
Broca’s aphasia
difficulty with speech production and comprehension
pure word deafness
damage to Wernicke’s area - can hear, read, speak, write, without recognizing the words. cannot repeat words spoken to them
transcortical sensory aphasia
damage to posterior language area - difficulty with comprehension and meaningful speech
Wernicke’s aphasia
damage to Wernicke’s area + posterior language area - difficulty in speech recognition, comprehension, and converting thoughts to words. fluent but meaningless speech
conduction aphasia
damage to the arculate fasciculus - difficulty repeating spoken words and non-words