Key Players in Cell Cycle

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Last updated 10:37 PM on 4/29/26

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MCM

unwind DNA

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ORC

marks beginning of replication, assembles copying machinery

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ORC-Cdc6

binds mcm helicase

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s-cdk

stimulates assembly of additional proteins on mcm helicase and prevent new mcm helicase loading by deactivating orc, cdc6 and cdt1

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ddk

phosphorylates subunits on mcm helicase

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cmg helicase

unwinds dna at origin

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geminin

protein that accumulates in s phase and inhibits cdt1 to prevent refiring