Chemo Bare Bones

When does breast cancer screening start

age 45-54, yearly mammogram

When does colorectal cancer screening start

45, stool tests or colonoscopy

When does lung cancer screening start

50-80 if smoker or hx of 20 pack years

Pack years

Packs per day X Years smoked

Carcinoma
Leukemia
Lymphoma
Sarcoma
Multiple Myeloma

Carcinoma	Epithelial cells
Leukemia	Bone marrow
Lymphoma	Lymphatic system
Sarcoma	Connective tissue (muscle, bone, cartilage)
Multiple Myeloma	Plasma cells fo bone marrow

Drugs that target M phase of cell cycle (Mitosis)

Taxanes (Taxels)

Vinca Alkoids (cristines)

Drugs that target S phase of cell cycle (DNA replication)

Anitmetabolites- Methoxtrexate, 5FU, Capcitabine

Topoisomerase I inhibitors - Irinotecan, topotecan

Drugs that target G2 phase of cell cycle (Growth)

Etoposide

Bleomycin

Drugs do not target specific cell cycle

Alkylating agents- cyclophosphamide,

Anthracyclines- Doxarubicin

Platinum compounds- Cisplatin, carboplatin, oxiplatin

BSA Equation

Square root of (Ht cm x Wtkg)/3600

Chemo Man

Chemo Extravasation Management

Taxanes boxed warning and management

Taxanes (eg, paclitaxel) have a boxed warning for hypersensitivity reactions and require premedication with a corticosteroid (eg, dexamethasone), histamine-1 receptor antagonist (eg, diphenhydramine), and histamine-2 receptor antagonist (eg, famotidine).

Target cancer therapies

tu= tumors eg rituximab

ci- circulators eg bevacizumab

li= immune eg ipilimumab

Breast Cancer treatment

IF HR positive (ER or PR +) and pre menopausal—> Tamoxifen

IF HR positive (ER or PR +) and post menopausal—> Tamoxifen or anastrazole

IF HER2+—> Add traztuzumab or pertuzumab

IF triple negative—> Taxanes and anthracyclines, no hormone therapies

Prostate Cancer Algorithm

GnRH Agonist (Leuprolide, Goserelin) + Antiandrogen (-mide)

or

GNRH antagonists (Degarelix, Relugolix)

Tumor Lysis Syndrome Effects

Hyperkalemia

Hypocalcemia

Hyperuricemia

Acute renal Failure