Growth Hormone Cascade

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Hypothalamus secretes GHRH
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GHRH affects somatotropic cells of anterior pituitary and they begin to produce growth hormone
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GH gets in the bloodstream and has both direct and indirect actions on target tissues
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increases amount of circulating GH triggers production of GHTH aka somatropin
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GHIH shuts off production of GHRH in order to stop production of GH