anti NEOPLASTIC - P1

LEUKEMIA

CHEM

• BENZENE =

CERVIAL CANCER

VIRUS

• HUMAN PAPILLO VIRUS =

Curative

Total eradication of cancer cells

• Lower tumor cell burden at which level host immunological defenses may keep the cells in control

Palliative

• Alleviation of symptoms, decrease tumor size, control growth

• Avoidance of life-threatening toxicity

• Increased survival and improved quality of lif

Adjuvant therapy

Attempt to eradicate microscopic cancer after surgery

Salvage Chemotherapy-

• an attempt to get a patient into remission, after previous therapies have failed

NeoAdjuvant

Chemotherapy is given to decrease the tumor burden before definitive therapy (surgery, radiation)

Remission

Oncologists prefer to use the term complete response or remission to indicate a patient with no evidence of disease after treatment.

log-kill hypothesis

chemotherapeutic agents kill a constant fraction of cells (first order kinetics), rather than a specific number of cells, after each dose

Cyclins

During the entire cycle, movement from one phase to the next is driven by proteins known as cyclins and their associated cyclin-dependent kinases (CDK)

G1

Tumor Cell Properties

• CHECK POINT

  • Is cell big enough?

  • Is DNA damaged?

METAPHASE checkpoint

Tumor Cell Properties

• CHECK POINT

  • Are chromosomes aligned on spindle?

G2

Tumor Cell Properties

• CHECK POINT

  • Is DNA replicated?

g2

Tumor Cell Properties

• RNA synthesis

s

Tumor Cell Properties

• DNA synthesis

g1

Tumor Cell Properties

• Early protein synthesis

g0

Tumor Cell Properties

• Restog phase

S PAHSE

target of

• antiMETABOLITES

METAPHASE

TARGET of

• PLANT ALKALOIDS

Autocrine Signaling

The ability of some cells to synthesize their own growth factors

apoptosis

programmed cell death