Digoxin

Digoxin

Digitek, Digox, Lanoxin

Digoxin drug class

digitalis glycoside

Digoxin dosage form

oral: tablet, solution

Digoxin ON label indication

1. Atrial fibrillation or atrial flutter

2. Heart failure with reduced ejection fraction

Digoxin OFF label indication

1. Fetal tachycardia, supraventricular tachycardia

2. Supraventricular tachycardia

Digoxin MOA

Digitalis glycosides exert positive inotropic effects through improved availability of calcium to myocardial contractile elements, thereby increasing cardiac output in heart failure. Antiarrhythmic actions are caused primarily by an increase in AV nodal refractory period via increased vagal tone, sympathetic withdrawal, and direct mechanisms.

Digoxin box warning

none

Digoxin contraindication

Hypersensitivity to digoxin, ventricular fibrillation

Digoxin pregnancy/breastfeeding

Compatible/Compatible

Digoxin adverse effects

none