Antibiotic medications

Gram +

purple stain, thin cell wall

Gram -

Pink- thick cell wall

what is the bacterial cell membrane composed of?

Glycan strands of NAG and NAM

What is NAG and NAM polymerized by, what are they translinked by?

Glycosyltransferase (GT) polymerize

Transpeptidase cross link

Do pathogens require to host to be injured?

NO, pathogens travel by their own

What are antibiotics

soluble compounds that are produced and release by microorganisms that inhibit growth or kill other microorganisms

INCLUDE SYNTHETIC AND SEMI-SYNTHETIC antimicrobial agents

Antibiotics have an NNT of what?

1, every person benefit when it was first introduced

What is central dogma of antibiotics

nO REPLICATION = No infection

What are 4 classes of antibiotics

Cell wall inhibitors, Folic Acid, DNA synthesis inhibitors, Protein synthesis inhibitors

Penicillin/Cephalosporins

Beta lactams, Cell wall inhibitor. STOP DD-Transpeptidase crosslink

Bactericidal. better on gram + PMCOL DYNAMIC

Vancomycin

NOT beta lactam, but also inhibit peptidglycan cross linkage

PABA (Para-aminobenzoic acid)

Precursor for folate A in bacteria, to make vitB12, and make purines

Sulfonamides(synthase) /trimethoprim (reductse)

resemble PABA, stop make folic acid

BACTERIOSTATIC

Bacteria 80s or 70s?

70S, use 30 and 50s ribosome tho

Chloramphenicol/Macrolides (C/M)

bind to 50s, block transpeptidation

Tetracyclines

Bind to 30s

Aminoglycosides

Bind to 30S, stop initiation of complex, cause misreading of code, inhibit translocation

Side effects of antibiotics

Can impact GI bacteria

Skin reactions/rash, should protect from sun

Steven-Johnson syndrome

when skin become detached from underlying tissue

what is pmcol KINETIC antibiotic drug resistance

bacteria make beta lactamases that stop antibiotics

alter metabolism to use preform folic acid instead

create efflux pumps to remove antibiotic from bacteria