WK9: 5HT receptor

Which 5-HT receptor is the target of triptans (e.g., sumatriptan) for migraine?

5-HT₁B and 5-HT₁D

What is the mechanism of triptans in migraine?

5-HT₁B/₁D agonists → vasoconstriction of cerebral blood vessels + inhibit CGRP release

Which 5-HT receptor is targeted by atypical antipsychotics like risperidone?

5-HT₂A (antagonist)

Which 5-HT receptor is the target of ondansetron?

5-HT₃ (antagonist)

What is ondansetron used for?

Chemotherapy-induced nausea and vomiting (anti-emetic)

Is 5-HT₃ a GPCR?

No – it is a ligand-gated ion channel

Which 5-HT receptor is associated with cardiac valve toxicity?

5-HT₂B (agonists can cause heart valve damage)

Which 5-HT receptor is targeted by buspirone for anxiety?

5-HT₁A (partial agonist)

Which 5-HT receptor is targeted by prucalopride for constipation?

5-HT₄ (agonist – increases GI motility)

Which migraine drug works on 5-HT₁F without causing vasoconstriction?

Lasmiditan

What type of drug is sumatriptan?

5-HT₁B/₁D agonist (triptan)

What type of drug is ondansetron?

5-HT₃ antagonist

What type of drug is risperidone?

5-HT₂A antagonist (also dopamine antagonist)

Why were fenfluramine and pergolide withdrawn?

Caused cardiac valve damage via 5-HT₂B agonism