Quiz #5 Non-Infectious Disease, Hypersensitivity

Anaphylactic Reactions & allergic/atopic reactions result from

specific antigens (allergens) binding to lgE antibodies which are bound to mast cells and basophils

List the factors that severity of the allergic reaction depends on

The route of exposure

The type of antigen

The amount of lgE antibodies already produced in the animal

The amount of antigen

What clinical signs are most often associated with shock in the cat?

Vomit, diarrhea, dyspnea, facial swelling

To treat type I hypersensitivities, what treatment would you expect a DVM to choose?

Supportive therapy based on the organ-specific disease process, to identify and eliminate the source of antigen, anti-inflammatory or immunosuppressive therapy if needed

An example of a Typa lI Hypersensitivity Reaction would be

• Drug induced hemolytic anemia

Most cats have what blood type?

A

Autoimmune thyroiditis is characterized by

Destruction of the gland by an autoimmune process that has both humoral and cell-mediated components

What drug therapy is chosen to treat most autoimmune disease

Immunosuppressive doses steroids

Main treatment for hypothyroidism

Levothyroxine

Osteosarcoma

Amputation

Hypoadrenocorticism

DOP and predisone

Diebetes Mellitus

Insulin

Hyperadrenocorticism

Trilostane

Pituitary pars intermedia dysfunction

Pergolide

Scurvy

Vitamin C

Entropian

Surgical Correction

Hyperthyroidism

Methimazole

Perianal fistula

Tacrolimus

Immune-mediated hemolytic anemia

Prednisone and cyclosporin

What is hyperthyroidism caused by? Is it considered an autoimmune metabolic and a metabolic disease?

Tumour on the thyroid gland, not considered autoimmune disease.

What is hypothyroidism is caused by? Is it considered an an autoimmune disease?

Immune mediated destruction of the thyroid gland

It is an autoimmune disease

What causes PPID

Overactivity of the pituitary gland

What is addison’s disease most often caused by?

Immune mediated destruction of the adrenal glands

What species are prone to urolithiasis because of too much calcium in their diet?

Guinea pigs

Why are guinea pigs prone to scurvy?

They cannot synthesize vitamin C.

What disease have been linked to grain free diets

DCM(dilated cardiomyopathy) in dogs.

Hypernatremia causes primarily what signs

neurological signs

All tumours are cancerous T or F

False

T or F, all malignant tumours metastasize

false

Carcinomas are tumours of epithelial cells

true

Beging tumours can metastizize

false

The most common site of metastasis is in the lungs

True

T or F, cancer can often be diagnosed on bloodwork

False

in dogs, the main organ affected by shock is the?

Liver

Cell mediated hypersensitivity type?

type 4

Anaphylactic shock

type 1

Anaphylactic shock: Hypersensitivity type?

Type 1

Immune complex: Hypersensitivity type?

Type 3

Cytotoxic Hypersensitivity type?

Type 2

Poison Ivy Hypersensitivity type?

Type 4

Hemolytic Disease of the Newborn Hypersensitivity type?

Type 2

Lupus Hypersensitivity type?

Type 3

Atopic skin disease

Type 1

KCS Hypersensitivity type?

Type 4

Blood transfusion reaction

Type 2

When testing for PPID, it is important to run an insulin panel to rule out what other common disease?

Equine Metabolic Syndrome (EMS).

What is the most common sequela of PPID

Laminitis