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Claude Bernard
Regulation of the internal environment was first described by French physiologist ____ in 1865
Homeostasis
Any self-regulating process by which biological systems tend to maintain stability while adjusting to conditions that are optimal for survival
Walter Cannon
The term homeostasis was coined by Harvard Neurophysiologist _____ in 1926.
Fight or flight and voodoo death
These terms were also coined by Walter Cannon
Dynamic constancy
Homeostasis is maintained by
Brain and hypothalamus
What makes up the control center for homeostatic regulation in the body.
Control center
Information from several systems must be integrated by the _____ in order to maintain values within the set-point range
Thermoregulation
Depends on dynamic constancy
Static constancy
Inanimate objects exhibit
Physical characteristic of the object
When a parameter, such as temp. of the object changes in response to changing the environmental temp., the return to the original temp. is dependent on the _______ and not a physiological response
Thermal conductivity
A property of a material that indicates its ability to conduct heat
0.138 W.m K
What is the thermal conductivity of pine wood
255 W.m K
What is the thermal conductivity of aluminum
0.49 W.m K
What is the thermal conductivity of muscle tissues
Set point
The normal range of values. Information from receptors and effectors are integrated by the control center to maintain values within the set point
Fever
What characterizes a change in hypothalmic set point, involves cytokines diurnal variation +, rarely exceeds 41 C, and complications are rare
Hyperthermia
What characterizes a failure thermoregulation, can exceed 41 C, can be detrimental, absence of diurnal variation
Negative feedback
All homeostatic mechanisms use ____ to maintain a constant value
Corrective mechanism
Negative feedback means that whenever a change occurs in a system, the change automatically causes a ____ to start, which reverses the original change and brings the system back to normal
Body temp., external environment, heart rate, blood pressure and volume
Examples of factors that influence a change in the homeostatic system include
Hemodynamics
Study of factors that effect blood flow through circulatory system
Postural changes
When standing still 60% blood volume pools in the veins of legs when standing still
Peripheral and central baroreceptors
Changes in pressure stimulate which receptors
Changes in heart rate and vascular resistance
Examples of changes in pressure
Peripheral baroreceptors
Specialized mechanoreceptors located in the carotid sinuses and aortic arch that detect blood pressure changes by sensing vessel wall stretch
Central baroreceptors
Specialized mechanoreceptors located in the carotid sinuses and aortic arch that detect changes in blood pressure, sending rapid, high-frequency action potentials to the medullary cardiovascular centers in the brain to regulate blood pressure and heart rate
Bradycardia
Slow heart rate
Vasodilation
Increase vessel diameter
Tachycardia
Fast heart rate
Vasoconstriction
Decrease vessel diameter
Cardiac ouput
Volume of blood leaving the heart in one minute
Posture and activity
Cardiac output changes with
CO=Heart Rate * Stroke Volume
What is the cardiac output formula?
Body mass, sex, fitness-level and health
Heart rate and stroke volume depend on what
Volume of blood leaving the heart
The volume of blood returning to the heart must equal
Hagen-Poiseuille statement
Flow is proportional to pressure difference and inversely proportional to resistance
Hagen-Poiseuille equation
Q=P1-P2/R
R=8nl(3.14)r4
For laminar flow in a tube, Poiseuilles law for resistance is defined as