Quiz on Intracellular Pathogens: Salmonella and Typhoid Fever/History of Microbiology

(for fill in the blank)

The following are characteristics of secondary antibodies except:  

their constant domain binds the variable domain of the primary antibody

The movement of proteins from the cytoplasm of Salmonella across the cell membranes of Salmonella and the cell membrane of a human cell directly uses energy from the proton motive force.  

False

Typhoid fever develops ______________ after exposure.

weeks

Salmonella-induced gastroenteritis begins __________________ after exposure.

hours

The following evidence support the endosymbiont theory as being correct except: 

the GC content of mitochondria and chloroplasts are similar to bacteria

If Salmonella typhimurium replicates to high levels in the bloodstream of a person, septic shock can occur because of ______________.

lipopolysaccharide

If you ate peanut butter contaminated with Salmonella typhimurium, what is the minimum number (minimum infectious dose) that you would need to ingest to develop gastroenteritis?  

100,000

Diarrhea results from Salmonella typhimurium-induced gastroenteritis by causing all of the following except:

sodium secretion

If PhoP is unphosphorylated in Salmonella, we can predict that:

Spi-1 genes will be expressed and Spi-2 genes will not be expressed

To survive inside a macrophage, Salmonella typhi requires all of the following virulence factors except:

Spi-1 type III secretion system

Salmonella induces membrane ruffling to enter cells. This process involves all of the following except:

Spi-2 type III secretion system

Please match the strain of Salmonella with the species that it is known to infect. The answers for Salmonella typhimurium must be in alphabetical order to earn credit.  Sorry, CANVAS won't give credit unless you use alphabetical order.  

Salmonella typhi

humans

Please match the strain of Salmonella with the species that it is known to infect. The answers for Salmonella typhimurium must be in alphabetical order to earn credit.  Sorry, CANVAS won't give credit unless you use alphabetical order.  

Salmonella typhimurium

C elegans (worm), cows, humans, mice, most mammals

Please pair each individual with the scientific contribution highlighted in the module.

Angelia Hesse

agar media

Please pair each individual with the scientific contribution highlighted in the module.

Anton van Leeuwenhoek

first to observe bacteria with a microscope

Please pair each individual with the scientific contribution highlighted in the module.

Robert Hooke

first to observe eukaryotic microorganisms

Please pair each individual with the scientific contribution highlighted in the module.

Francisco Redi

disproved spontaneous generation

Please pair each individual with the scientific contribution highlighted in the module.

Louis Pasteur

germ theory of disease

Please pair each individual with the scientific contribution highlighted in the module.

Robert Koch

postulates to prove a microbe causes a specific disease

Please pair each individual with the scientific contribution highlighted in the module.

Joseph Lister

antiseptic surgery

Please pair each individual with the scientific contribution highlighted in the module.

Alexander Fleming

discovered penicillin

Please pair each individual with the scientific contribution highlighted in the module.

Lynn Margulis

endosymbiont theory

Please pair each individual with the scientific contribution highlighted in the module.

Edward Jenner

protection from smallpox from cowpox

Please match each step of the 4 postulates to prove a microorganism causes a disease with its application to Lyme Disease.

Microbe always present in diseased and absent in the healthy

Isolate Borrelia burgdorferi only from people with Lyme disease

Please match each step of the 4 postulates to prove a microorganism causes a disease with its application to Lyme Disease.

Microbe grown in pure culture

Isolate single colonies of Borrelia burgdorferi from ticks

Please match each step of the 4 postulates to prove a microorganism causes a disease with its application to Lyme Disease.

Introduce pure microbe into healthy individual

let infected ticks bite rabbits

Please match each step of the 4 postulates to prove a microorganism causes a disease with its application to Lyme Disease.

Same microbe re-isolated from now-sick individual

See rash in rabbits and isolate Borrelia burgdorferi from rabbits