Pharm 2 Final: Antifungal and Antiviral

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Last updated 1:58 PM on 4/25/26
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6 Terms

1
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Amphotericin B

MOA: Polyene antibiotic; binds fungal cell membrane and increases membrane permeability. Use: Systemic and subcutaneous fungal infections (PO and IV). SE: "Ampho-terrible" — renal and multi-organ toxicities.

2
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Nystatin

MOA: Polyene antibiotic; binds fungal cell membrane and increases membrane permeability. Use: Candida infections. SE: Oral or topical use only.

3
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Clotrimazole

MOA: Inhibits ergosterol synthesis. Use: Candida infections of mouth, throat, vagina, vulva; dermatophyte infections. SE: Oral and topical formulations.

4
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Fluconazole

MOA: Inhibits ergosterol synthesis. Use: Cryptococcal meningitis (AIDS patients), vaginal candidiasis. SE: Excellent CSF penetration.

5
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Ketoconazole

MOA: Inhibits ergosterol synthesis. Use: Seborrheic dermatitis. SE: Oral and topical formulations.

6
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Terbinafine

MOA: Inhibits ergosterol synthesis. Use: Onychomycosis. SE: Typically used orally when topical therapy has failed.