auto in class questions 4/14

all of the following about reserpine are correct EXCEPT

a. causes less hypotension than clonidine

b. may increase suicide risk

c. causes NTs to leak into cytoplasm

d. depletes NE,DA,5HT, and histamine

e. action involves metabolism by the enzyme MAO

a. causes less hypotension than clonidine

false. it causes more

all of the following about reserpine are correct except

a. binds tightly to monoaminergic storage vesicles and destroys them

b. more effective of VMAT1 than VMAT2`

c. decreases renin release

d. decreases TPR

e. decreases CO

b. more effective of VMAT1 than VMAt2

false. more effective of VMAT2 (less effective at chromaffin cells)

all of the following about guanethidine are true except

a. binds to NET

b. can serve as an inactive false NT

c. administration can result in supersensitive effector cells

d. crosses BBB

d. crosses BBB

all of the following about guanethidine are true except

a. decreases preload

b. decreases afterload

c. decreases capacitance

d. decreases TPR

e. decreases cardiac output

f. can cause effector cells to become supersensitive

c. decreases capacitance

false. it increases capacitance

all of the following drugs would be expected to inhibit guanethidine transport into adrenergic terminals except

a. cocaine

b. amphetamine

c. some antidepressants

d. hemicholinium

d. hemicholinium

others inhibit NET

an increase in tissue sensitivity to an agonist bc of up regulation may involve

a. increased receptor mRNA

b. increased number of receptors inserted into membrane

c. altered signal transduction

d. 2 of above

e. all of above

e. all of the above

down regulation of NT receptors will most readily be observed following administration of

a. full agonists

b. partial agonists

c. antagonists

a. full agonists

antagonists would cause up regulation

which of the following drugs has a MOA similar to guanethidine

a. guanabenz

b. guanfacine

c. guanadrel

c. guanadrel

others are alpha 2 agonists

all of the following are true about metyrosine except

a. decreases catecholamine synthesis

b. causes orthostatic hypotension

c. inhibits rate limiting enzymatic step

d. should NOT be combined with adrenergic receptor antagonists

d. should NOT be combined with adrenergic receptor antagonists

false. often combined for pheochromocytoma tx

hemicholinium

a. increases choline availability

b. increases ACh synthesis

c. binds to choline transporter (ChT)

d. directly inhibits choline acetyl transferase

c. binds to ChT

all of the following about vesamicol are true except

a. binds to VAChT

b. depletes ACh stores

c. is used therapeutically to decrease wrinkles in skin

c. is used therapeutically to decrease wrinkles in skin

all of the following about botox are true except

a. originates from bacteria

b. enters cholinergic terminals via endocytosis

c. displaces ACh and causes depletion of ACh

d. can cause death at very low doses

e. is used therapeutically

c. displaces ACh and causes depletion of ACh

affects fusion of vesicle; prevents release

all of the following about pheochromocytoma are true except

a. tumor of adrenal medulla

b. often involves elevated secretion of catecholamines into blood

c. can be associated with hemodynamic instability

d. best managed by giving non-selective beta antagonist

e. tx may involve surgery

d. best managed by giving non-selective beta antagonist

blocking beta 2 will prevent vasodilation and make it worse

micturition

a. does not involve higher CNS areas and is completely controlled by brain stem/spinal mechs

b. neuronal circuitry includes local spinal reflex

c. involves symp facilitated contraction of detrusor

d. involves parasymp contraction of external urethral sphincter

b. neuronal circuitry includes local spinal reflex (true)

a. is wrong. involves CNS bc we have some voluntary control that overrides reflex

c and d are flipped. parasymp contracts detrusor