BLOOD DONATION and BLOOD COMPONENT PREPARATION

DIRECTED

Blood is intended for the use of specific patient

F

A donation in which the recipient chooses the donor

DIRECTED

T/F

A donation in which the recipient cannot chooses the donor

TRUE

DIRECTED

T/F

Blood from directed donors is no safer than blood from the volunteer blood supply

whole blood donation

Allogeneic Commonly referred to

Allogeneic

Blood donated is intended for the use of general patient population

mass blood donation

Example of Allogeneic

Autologous

Blood donated by the owner for future use

Donor-patient

The autologous donor is referred to as the ____-_____

APHERESIS

Blood donation in which a specific component of the blood is only extracted, and the remaining components are returned to the donor

2-3 hrs

The process of apheresis takes about

specific gravity or weight

In apheresis, Separation of components is based on specific gravity or weight

Blood is processed in batches or cycles (passes).

Intermittent Flow Centrifugation (IFC)

Blood is processed in ______ or _____ (passes).

1. Draw - whole blood is drawn with a pump

2. Spin components are centrifuged

3. Dwell & Surge - separation of desired and undesired components

4. Return reinfusion of undesired components

Steps in Intermittent Flow Centrifugation (IFC)

Continuous Flow Centrifugation (CFC)

The process of withdrawal, processing, and reinfusion of the blood is performed simultaneously in a continuous manner.

Two venipuncture sites are needed.

In CFC, ____ venipuncture sites are needed.

thrombocytopheresis

Plateletpheresis

Otherwise known as

≥75%

Plateletpheresis

____ of platelet transfusions

Single Donor Platelet (SDP)

One plateletpheresis unit is equivalent to 6-8 random donor platelets

A unit is called _____ _____ ____

6-8 random

plateletpheresis

One plateletpheresis unit is equivalent to _____ donor platelets

Plasmapheresis

1st product to be collected by apheresis

source plasma and plasma derivatives

Plasmapheresis Used to obtain "____ ____ " - converted into ____ ____

Infrequent/occasional

Donates not more than once in 4-weeks

Serial

Donates not more than once every 48 hours; Not more than twice in 7 days

leukocytes and granulocytes

Apheresis is the only effective method for collecting ______ , specifically, _______

TRUE

Leukapheresis

T/F

Donors are given drugs or sedimenting agents to increase the recovery of WBCs

Hydroxyethyl starch (HES)

Prednisone

Dexamethasone

Growth factors

Types of drugs in Leukapheresis

Erythrocytapheresis

Double RBC Pheresis - 2 units of red cells are collected using apheresis

16 weeks

Erythrocytapheresis

Successful completion

<8 weeks

Erythrocytapheresis

Red cell loss <200 mL

8 weeks

Erythrocytapheresis

Red cell loss >200 ml but <300 mL

16 weeks

Erythrocytapheresis

Red cell loss >300 mL

HPC Pheresis

Collection of hematopoietic progenitor cells (HPCs) or peripheral blood stem cells (PBSCs)

FALSE

increase

HPC Pheresis

T/F

Hematopoietic growth factors, particularly GCSF, is used to decrease the number of circulating stem cells prior to the procedure

16 weeks

2RBC

Every 2 days (≤2x in 7 days)

Plasma (frequent)

Every 4 weeks

(≤13x/year)

Plasma (infrequent)

Every 2 days (≤2x/in 7 days; ≤24x/year)

Platelets, single apheresis unit

Every 7 days

Platelets, double triple apheresis unit

Every 2 days

Granulocytes