Top 300 Quiz 12

AMITRIPTYLINE

brand

Elavil

AMITRIPTYLINE

Oral Tablet

10 mg, 25 mg, 50 mg, 75 mg, 100 mg, 150 mg

AMITRIPTYLINE

Common FDA Label Indication, Dosing, and Titration

Depression

AMITRIPTYLINE

MOA

TCA

AMITRIPTYLINE

Box Warnings

Suicidality in young adults, adolescents, and children

AMITRIPTYLINE

Contraindications

MAOI

acute recovery period after MI

coadministration of cisapride

AMITRIPTYLINE

Adverse Reactions

Sedation

Cardiac dysrhythmia

hepatotoxicity

seizures

suicidal thoughts

AMITRIPTYLINE

Key Patient Counseling Points

Avoid activities requiring mental alertness

improvement may not be seen for a few weeks

Avoid sudden discontinuation

GABAPENTIN

brand

Neurontin, Gralise

GABAPENTIN

Dosage Forms

Capsule

Tablet

Solution

Tablet, ER

GABAPENTIN

Capsule

100 mg, 300 mg, 400 mg

GABAPENTIN

Tablet

600 mg, 800 mg

GABAPENTIN

Solution

250 mg/5 mL

GABAPENTIN

Tablet, Extended Release

300 mg, 600 mg

GABAPENTIN

Common FDA Label Indication, Dosing, and Titration

Partial seizure

Postherpetic neuralgia

GABAPENTIN

MOA

Gamma Aminobutyric Acid Analog

cyclohexane structurally related to GABA

GABAPENTIN

Dose Adjustment Renal

yes

GABAPENTIN

Adverse Reactions

Ataxia, dizziness

Stevens-Johnson syndrome

suicidal thoughts

GABAPENTIN

Key Patient Counseling Points

1st dose at bedtime

ER formulation + meal

avoid activities requiring mental alertness

Avoid sudden discontinuation

Wait 2 h after antacid

can open contents and mix

LATANOPROST

brand

Xalatan, Xelpros, Iyuzeh

LATANOPROST

Dosage Forms

Ophthalmic Solution

Ophthalmic Emulsion

LATANOPROST

Ophthalmic Solution

Ophthalmic Emulsion

0.005%

LATANOPROST

Common FDA Label Indication, Dosing, and Titration

Ocular HTN, open-angle glaucoma

LATANOPROST

MOA

prostaglandin F2-alpha analog

increased uveoscleral outflow

LATANOPROST

Contraindications

Hypersensitivity to latanoprost or benzalkonium chloride

LATANOPROST

Adverse Reactions

Blurred vision

foreign body in eye

hyperpigmentation of eyelid

Macular retinal edema

diplopia, keratitis

toxic epidermal

necrolysis

iris cyst

uveitis

LATANOPROST

Key Patient Counseling Points

Wash hands and remove contact lenses

Separate others by 5 min

NABUMETONE

brand

Relafen

NABUMETONE

Tablet

500 mg, 750 mg, 1000 mg

NABUMETONE

Common FDA Label Indication, Dosing, and Titration

Osteoarthritis

Rheumatoid arthritis

NABUMETONE

MOA

6-methoxy-2-naphthylacetic acid (6MNA)

COX-1/2 → NSAID

NABUMETONE

Dose Adjustment Renal

yes

NABUMETONE

Box Warnings

Thrombotic events; GI bleeding

NABUMETONE

Contraindications

Hypersensitivity to NSAIDs, aspirin or sulfonamides

concurrent ketorolac, pentoxifylline use; asthma, CABG surgery

NABUMETONE

Adverse Reactions

Elevated LFTs

dyspepsia

abdominal pain

thrombosis

acute renal failure

CHF

aplastic anemia

NABUMETONE

Key Patient Counseling Points

food or milk to decrease GI upset

SITAGLIPTIN

generic

Januvia, Zituvio

SITAGLIPTIN

Common FDA Label Indication, Dosing, and Titration

Diabetes mellitus Type 2

SITAGLIPTIN

MOA

DPP-4 enzyme inhibitor

SITAGLIPTIN

Dose Adjustment Renal

yes

SITAGLIPTIN

Adverse Reactions

Hypoglycemia

Pancreatitis

rhabdomyolysis

severe arthralgias

SITAGLIPTIN

Key Patient Counseling Points

BG: 2-4 times/d

morning meal: once-daily dosing

combo with insulin / sulfonylureas → hypoglycemia