[PCOG-LEC-FIN-02-PT3] PEPTIDE HORMONES & THE ENDOCRINE SYSTEM

THIS FLASHCARDS IS ABOUT [PCOG] ADRENAL GLANDS: EPINEPHRINE, NOREPINEPHRINE, AND DOPAMINE.

(-)-3,4-dihydroxy-a-[(methylamino)methyl] benzyl alcohol

What is the chemical structure name of Epinephrine?

1. Hormone

2. Synthetically

Epinephrine may be isolated as a (1)_____ in adrenal medulla or may be prepared (2)_____.

B1 (heart) > B2 (lungs) = a1

What is the affinity to receptors of Epinephrine?

Epinephrine

This is the 1st line agent in cardiac stimulant in ACLS.

Advanced Cardiac Life Support

ACLS stands for?

Cardiac stimulant

Epinephrine is the 1st line agent in ______________ in ACLS.

Epinephrine

This is the 1st line agent in the management of anaphylaxis.

Anaphylaxis

Epinephrine is the 1st line agent in the management of?

Local vasoconstrictor

Epinephrine is also used as a?

Epinephrine

This is used in the management of open-angle glaucoma.

Open-angle glaucoma

Epinephrine is used in the management of?

Dipivefrin

Which drug is used in the management of open-angle glaucoma?; this is the pivalic acid ester of epinephrine.

Dipivefrin

What is the prodrug of epinephrine?

Levarterenol

Norepinephrine is marketed under what brand name?

(-)-a-(aminomethyl)3,4-dihydroxybenzyl alcohol

What is the chemical structure name of Norepinephrine?

Norepinephrine

This is a sympathetic stimulant closely related in chemical structure and pharmacological action to Epinephrine.

B1 > a1

What is the affinity to receptor of Norepinephrine?

Brown color ppt

The instability of norepinephrine can be seen via?

(Do not use it anymore because it is unstable already)

Sympathetic stimulant

Norepinephrine is used as a?

Strong peripheral vasoconstrictor

Norepinephrine is also used as a strong _____________.

Norepinephrine

This is used as a 1st line inotropic agent in the management of septic shock.

Septic shock

Norepinephrine is used as a 1st line inotropic agent in the management of?

Norepinephrine

This is also used as an alternative in the management of acute heart failure and cardiogenic shock.

1. Acute heart failure

2. Cardiogenic shock

Norepinephrine is also used as an alternative in the management of (1) acute _______________ and (2)________ shock.

3,4-dihydroxyphenylethylamine

What is the chemical structure name of Dopamine?

Dopamine

This is the biosynthetic precursor of NE and EPI and has a sympathomimetic properties.

• Epinephrine

• Norepinephrine

Dopamine is the biosynthetic precursor of?

D1 > B1 > a1

What is the affinity to receptors of Dopamine?

Dose-dependent

The response of adrenergic receptors to dopamine is?

1. D1 receptors

2. Renal vasodilation

3. Diuresis

Examples of Dose-dependent:

1-3 mcg/kg/min stimulates (1)_____ receptor causing (2)_____ vasodilation resulting to (3)_____.

1-3 mcg/kg/min

This dose stimulates D1 receptors causing renal vasodilation resulting to diuresis.

1. B1 receptor

2. Inotropic effect

Examples of Dose-dependent:

2-5 mcg/kg/min stimulates (1)_____ receptor causing (2)_____ effect.

2-5 mcg/kg/min

This dose stimulates B1 receptor causing inotropic effect.

1. a1

2. Vasoconstriction

Examples of Dose-dependent:

>5 mcg/kg/min stimulates (1)_____ receptor causing (2)_____.

>5 mcg/kg/min

This dose stimulates a1 receptor causing vasoconstriction.

Cardiogenic and Septic Shock

Dopamine is used in the management of (2)?

Hint: Car-Sep

Dopamine

This is used for acute heart failure complicated by oliguria or anuria because of its diuresis effect.

1. Acute heart failure

2. Oliguria or Anuria

Dopamine is used for (1)____ heart failure complicated by (2)_____ or _____.

Dopamine

This is also used in the treatment of cardiac decompensation.

Cardiac decompensation

Dopamine is also used in the treatment of?

IV infusion

Dopamine is usually administered via?