Tuberculosis Treatment Regimens

A collection of vocabulary-style flashcards covering WHO standard and shortened treatment regimens for drug-susceptible and drug-resistant tuberculosis.

Standard 6-month TB Regimen (Mnemonic)

$2$HRZE / $4$HR

Intensive Phase (Standard 6-month Regimen)

The first $2$ months consisting of Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), and Ethambutol (E).

Continuation Phase (Standard 6-month Regimen)

The next $4$ months consisting of Isoniazid (H) and Rifampicin (R).

New WHO 4-month Regimen (Eligibility)

Adults and children aged 12 years or older with a body weight of more than 40 kg and affected by pulmonary DS-TB are eligible for this regimen, including those who are also HIV-positive with a CD4 count of more than 100 cells/mm³ and patients with diabetes.

New WHO 4-month Regimen (Mnemonic)

$2$HPMZ / $2$HPM

Intensive Phase Components (First 2 Months of 4-month Regimen)

Isoniazid ($300\,mg$ daily), Rifapentine ($1200\,mg$ daily), Moxifloxacin ($400\,mg$ daily), and weight-based Pyrazinamide daily.

Continuation Phase Components (Next 2 Months of 4-month Regimen)

Isoniazid ($300\,mg$ daily), Rifapentine ($1200\,mg$ daily), and Moxifloxacin ($400\,mg$ daily).

Pyrazinamide Weight-Based Dosages ($40-<55\,kg$)

$1000\,mg$ daily.

Pyrazinamide Weight-Based Dosages ($55-75\,kg$)

$1500\,mg$ daily.

Pyrazinamide Weight-Based Dosages ($>75\,kg$)

$2000\,mg$ daily.

MDR/RR-TB

Multidrug-resistant or rifampicin-resistant TB.

BPaLM Regimen

A $6$-month regimen for MDR/RR-TB if fluoroquinolone susceptible, consisting of Bedaquiline, Pretomanid, Linezolid, and Moxifloxacin.

BPaL Regimen

A $6$-month regimen for MDR/RR-TB if fluoroquinolone resistant or intolerant, consisting of Bedaquiline, Pretomanid, and Linezolid.