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Three factors that affect Reactivity of Nucleophilic Acyl Substitution Reactions (1)
Nucleophiles react more readily with unhindered carbonyl groups
Three factors that affect Reactivity of Nucleophilic Acyl Substitution Reactions (2)
The intermediate with the best leaving group (weaker base is a better leaving group) react faster (CATEA)
Three factors that affect Reactivity of Nucleophilic Acyl Substitution Reactions (3)
Electrophilic carbonyl groups (with neighboring EWGs) are more reactive to addition
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