HIV/AIDS Nucleoside Reverse Transcriptase

Pnemonic

ZALES DT

NRTIs Side Effects

Headache, lactic acidosis, hepatic steatosis, RENAL (Except Abacavir), and take with or without food (except didanosine)

Zidovudine -IV

AZT-ZDV- Retrovir

Zidovudine Side Effects

Bone Marrow Suppression-Black Box, anemia- Tx Epogen, Neutropenia- Tx Neupogen,

Lactic acidosis and hepatic steatosis- black box

Myopathy- black box (like statins and daptomyocin)

headache, purple nails

Abacavir

ABC-Ziagen

Testing for Abacavir hypersensitivity reaction

HLA-B 5701 (Allopurinol -5801) (Carbamazapine 1502)

Abacavir and Lamivudine

Epzicon

Abacavir and Lamivudine and Zidovudine -BID

Trizivir

Abacavir and Lamivudine and Dolutegravir - QD

Triumeq

Abacavir Side Effects

Lamivudine

3TC-Epivir- Epivir-HBV

Emtricitabine

FTC-Emtriva

Emtracitabine

Capsule and Oral(in fridge)

Emtracitabine

Chemically similar to Lamivudine

Stavudine

d4T- Zerit

Stavudine Other Side Effects

Pancreatitis and Peripheral Neuropathy

DidanOsine

ddI-Videx-Videx EC

DidanOsine

On empty stomach

DidanOsine

Check Eyes -avoid alcohol

Tenofovir

TAF and TDF

TAF

Tenofovir Alafenamide (Vemlidy)-

TAF Asocciation

Fewer bone and kidney toxicities that TDF

TDF

Tenofovir Disproxil Fumarate (Viread)

TDF Associations

lower lipid levels than TAF- better in Diabetes (D)

TAF Indication

Chronic Hepatitis B