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Maximum daily dose for non-prescription ibuprofen
1200 mg
Maximum daily dose for non-prescription acetaminophen
4000 mg
Maximum daily dose for non-prescription naproxen
660 mg
Pediatric dosing for ibuprofen
5-10 mg/kg/dose
Frequency of pediatric ibuprofen
every 6-8 hours
Maximum daily dose of pediatric ibuprofen
1200 mg OR 4 doses/day
Pediatric dosing for acetaminophen
10-15 mg/kg/dose
Frequency of pediatric acetaminophen
every 4-6 hours
Maximum daily dose of pediatric acetaminophen
2400 mg
Maximum daily dose of pediatric acetaminophen in neonates (<3 mo)
10-15 mg/kg/dose every 6-8 hours
Dextromethorphan indication
antitussive
Guaifenesin indication
expectorant
Pseudoephedrine indication
decongestant
Phenylephrine indication
decongestant
Diphenhydramine indication
1st generation antihistamine
Doxyalamine indication
1st generation antihistamine
Bulk forming for constipation MOA
absorbs water to soften stool
Examples of bulk forming medications for constipation
psyllium (MetaMucil)
methylcellulose (Citrucel)
(hyper) osmotic for constipation MOA
draws out water into the colon/r*ctum
Examples of (hyper) osmotic medications for constipation
PEG or polyethylene glycol (Miralax)
glycerin suppositories
lactulose
magnesium citrate
Stimulants for constipation MOA
stimulate intestine to secrete water
Examples of stimulant medications for constipation
senna (Senokot)
bisacodyl (Dulcolax)
Emollient/stool softener for constipation MOA
mix aqueous and fatty substances to soften stool
Example of emollient/stool softener for constipation
docusate (Colace)
Secretagogues for constipation MOA
increase intestinal fluid secretion and motility indirectly
Examples of secretagogues for constipation
lubiprostone (Amitiza)
linaclotide (Linzess)
plecanatide (Trulance)
Saline for constipation MOA
draws water into intestines to stimulate movement
Examples of saline for constipation
MOM
Fleet
Lubricant for constipation MOA
coats stool to prevent water absorption
Example of lubricant for constipation
mineral oil
Indication for all NRT
smoking cessation
helps reduces nicotine withdrawal symptoms
Dosing schedule for gum NRT
weeks 1-6: 1 piece every 1-2 hours
weeks 7-9: 1 piece every 2-4 hours
weeks 10-12: 1 piece every 4-8 hours
Doses available for gum NRT
2mg (if smoking >30 mins after waking)
4mg (if smoking <30 mins after waking)
Maximum daily dose for gum NRT
24 pieces/day
Counseling points for gum NRT
Chew and park technique
Avoid food/drinks 15 mins before and during use
Not recommended for TMJ
May experience flatulence, nausea, mouth irritation
Dosing schedule for lozenge NRT
weeks 1-6: 1 lozenge every 1-2 hours
weeks 7-9: 1 lozenge every 2-4 hours
weeks 10-12: 1 lozenge every 4-8 hours
Doses available for lozenge NRT
2mg (if smoking >30 mins after waking)
4mg (if smoking <30 mins after waking)
Maximum daily dose for lozenge NRT
20 lozenges/day
Counseling points for lozenge NRT
Let fully dissolve
Do not chew or swallow whole
Move lozenge around to different parts of the mouth
Do not eat/drink 15 mins before and during use
May experience flatulence, nausea, mouth irritation
Dosing schedule for patch NRT
If >10 cigs/day
start 21 mg daily for 4-6 weeks
then 14 mg daily for 2 weeks
then 7 mg daily for 2 weeks
If <10 cigs/day
start 14 mg daily for 6 weeks
then 7 mg daily for 2 weeks
Doses available for patch NRT
7mg, 14mg, 21mg
Counseling points for patch NRT
Apply daily to the upper body (clean, dry, hairless)
Rotate application sites
Remove at bedtime if experiencing sleep disturbances or vivid dreams
Able to swim and bathe with patch on
Do not cut patch
Wash hands after applying
May experience skin irritation
Inactivated vaccines [generic (brand)]
influenza (Fluzone)
COVID-19 (SPIKEVAX)
hepatitis A (Havrix)
hepatitis B (Energix-B)
hep A/B (Twinrix)
HPV (Gardasil9)
pneumococcal (Prevnar 20)
RSV (Abrysvo)
Tdap (Boostrix)
Hib (ActHIB)
polio (Ipol)
MenACWY (MenQuadfi)
MenB (Trumenba)
Shingles (Shinrix)
Live vaccines [generic (brand)]
MMR (Priorix)
varicella (Varivax)
intranasal influenza
Yellow Fever (YF-Vax)
rotavirus (RotaTeq)
dengue
Mpox (Jynneos)
typhoid (Vivotif)
Iron Deficiency Anemia lab findings
ferritin <45 ng/mL
Tsat <20%
Low Hgb, Hct, HCHC, Fe
High TIBC
Iron Deficiency Anemia classification
Microcytic
MCV <80
Iron Deficiency Anemia treatment
ferrous sulfate 325 (65-200mg elemental iron)
every other day OR MWF for 3-6 months
1 hour before meals
ferric gluconate (Ferrlecit) 125mg IV
over 1 hour
dietary iron
meat, fish, poultry
vit C increases absorption
milk, tea, antacids decrease absorption
blood transfusions
Hb less than 7
active bleeding/unstable hemodynamics
Megaloblastic Anemia classification
Macrocytic
MCV >100
Megaloblastic Anemia lab findings
vitamin B12 <200 pg/mL, with normal folate
OR
folate <4 mg/mL, with normal vitamin B12
Megaloblastic Anemia treatment
vitamin B12 deficiency: 1000-2000mcg once daily
with neurological issues: IM/SQ 1000mcg once daily for 1 week, 1000mcg weekly for 2 weeks, then1000mcg monthly
folic acid deficiency: folic acid 1mg once daily for 4 months OR until underlying causes are corrected
with absorption issues: IV/IM/SQ folic acid 1mg once daily for 4 months or until underlying causes are corrected
gastric bypass surgery: prevention for life
Anemia in CKD lab findings
CrCL <60 mL/min
Hb <13 in men; <12 in women
(CKD w HD) ferritin <500 and Tsat <30%
(CKD wo HD) ferritin <100 and Tsat <40% OR ferritin >100 and <300 w Tsat <25%
Anemia in CKD treatment
oral iron
trial 1-3 months for pts not on dialysis
IV iron
ferric gluconate: 125mg IV three times per week for 8 doses
ESA if HB <9.0-10.0
CKD w HD
IV/SQ: 50-100 units/kg three times per week (IV preferred)
CKD wo HD
IV/SQ: 50-100 units/kg once weekly
1st line treatments for Hepatic Encephalopathy
lactulose
20-30g (30-45mL) every 1-2 hours to induce ~2 soft stools/day
reduce to 20-30g (30-45mL) every 2-4 times daily
ensure about 2-3 soft stools/day
rifaximin
550mg for ppx
400mg for tx
Other treatments for Hepatic Encephalopathy
metronidazole (Flagyl): 250mg PO Q6-12h
neomycin: 1g PO TID
rarely used due to severity of potential adverse effects like ototoxicity and nephrotoxicity
zinc: 600mg PO once daily
polyethylene glycol (similar to action of lactulose)
Examples of SSRIs [generic (brand)]
fluoxetine (Prozac)
sertraline (Zoloft)
escitalopram (Lexapro)
citalopram (Celexa)
paroxetine (Paxil)
Adverse effects of SSRIs
nausea, headache, diarrhea, insomnia, restlessness/nervousness, sexual dysfunction
Contraindications of SSRIs
MAOIs, concurrent linezolid, concurrent IV methylene blue
Black Box Warning for ALL antidepressants
increased suicidal thoughts and behaviors
Examples of SNRIs [generic (brand)]
duloxetine (Cymbalta)
venlafaxine (Effexor)
desvenlafaxine (Pristiq)
levomilnacipran (Fetzima)
milnacipran (Savella)
Adverse effects of SNRIs
nausea, dizziness, sweating, hypertension, orthostatic hypotension
Contraindications of SNRIs
MAOIs
Adverse effects of Bupropion (Wellbutrin)
anxiety, insomnia, nausea, restlessness, seizure risk
DDIs to Bupropion (Wellbutrin)
substrate of CYP2B6, potent CYP2D6 inhibitor
Contraindications of Bupropion (Wellbutrin)
seizures, eating disorder
Adverse effects of Mirtazapine (Remeron)
sedation, weight gain, dizziness, hyperlipidemia, leukopenia
Contraindications of Mirtazapine (Remeron)
MAOIs
MOA of 1st generation antipsychotics
D2 antagonist
Blocks dopamine receptor, reduces excess
Targets D2 receptor in mesolimbic pathway calming hyperdopaminergic activity to treat positive symptoms of schizophrenia
Examples of 1st generation antipsychotics [generic (brand)]
haloperidol (Haldol)
chlorpromazine
thiothixene (Navane)
fluphenazine
MOA of 2nd generation antipsychotics
D2 antagonist and 5HT2A serotonin receptor antagonist
Blocks both dopamine and serotonin, mostly serotonin
Examples of 2nd generation antipsychotics [generic (brand)]
aripiprazole (Abilify)
olanzapine (Zyprexa)
clozapine (Clozaril)
Medications used for AUD [generic (brand)]
naltrexone (Vivitrol)
gabapentin (Neurontin)
acamprosate (Camprol)
disulfiram (Antabuse)
Adverse effects of Naltrexone (Vivitrol)
N/V, anxiety/insomnia, headache, hepatotoxicity, depression/suicidal thoughts
Contraindications of Naltrexone (Vivitrol)
opioid use, withdrawal, positive screen, acute hepatitis, severe liver failure
must be opioid free for 7-10 days
Adverse effects of Gabapentin (Neurontin)
sedation, fatigue, dizziness, ataxia
respiratory depression when taken along with opioids or CNS depressants
suicidal ideation
Contraindications of Gabapentin (Neurontin)
renal dose adjustment needed, caution in elderly patients, respiratory disease, concurrent opioid/benzo use