Week 7: Anemia and Respiratory Drugs

True or False: A major concern for patients with Sickle Cell Disease is Vaso-Occlusive Crisis, which can result in ischemia, pain, necrosis and often organ damage.

true

Which Respiratory Monoclonal Antibody Drug has a mechanism of action of: a monoclonal antibody that binds to the interleukin-4 receptor subunit alpha (IL-4R$\alpha$A), which blocks signaling of both IL-4 and IL-13, key drivers of allergic inflammation, immune responses to parasites, and tissue remodeling that occur in asthma.

a. Omalizumab (Xolair)

b. Tezepelumab-ekko (Tezpire)

c. Mepolizumab (Nucala)

d. Benralizumab (Fasenra)

e. Dupixent (dupilmab)

e. Dupixent (dupilmab)

Which Respiratory Monoclonal Antibody Drug has a mechanism of action of: A monoclonal antibody drug that binds to free IgE, which lowers free IgE levels that are able to bind to mast cells to eventually cause release histamine –>Allergic Asthma

a. Omalizumab (Xolair)

b. Tezepelumab-ekko (Tezpire)

c. Mepolizumab (Nucala)

d. Benralizumab (Fasenra)

e. Dupixent (dupilmab)

a. Omalizumab (Xolair)

Which Respiratory Monoclonal Antibody Drug has a mechanism of action of: a monoclonal antibody drug that works by binding to circulating interleukin-5 (IL-5) to prevent it from binding to the IL-5 receptor on eosinophils, reducing  eosinophils ability to cause chronic inflammation, tissue damage, airway hyperresponsiveness, and remodeling (thickening of airway walls) in the airways.

a. Omalizumab (Xolair)

b. Tezepelumab-ekko (Tezpire)

c. Mepolizumab (Nucala)

d. Benralizumab (Fasenra)

e. Dupixent (dupilmab)

c. Mepolizumab (Nucala)

Which Respiratory Monoclonal Antibody Drug has a mechanism of action of: It is a monoclonal antibody that targets and blocks the “antigen”- cytokine -------thymic stromal lymphopoietin (TSLP)----- , which reduces inflammation, helping to prevent severe athma attacks and improve breathing.

a. Omalizumab (Xolair)

b. Tezepelumab-ekko (Tezpire)

c. Mepolizumab (Nucala)

d. Benralizumab (Fasenra)

e. Dupixent (dupilmab)

b. Tezepelumab-ekko (Tezpire)

Which Respiratory Monoclonal Antibody Drug has a mechanism of action of: a monoclonal antibody drug that binds to the actual IL-5 receptor (IL-5R) on eosinophils, causing rapid depletion of esosinophils, reducing their ability to to cause chronic inflammation, tissue damage, airway hyperresponsiveness, and remodeling (thickening of airway walls) in the airways.

a. Omalizumab (Xolair)

b. Tezepelumab-ekko (Tezpire)

c. Mepolizumab (Nucala)

d. Benralizumab (Fasenra)

e. Dupixent (dupilmab)

d. Benralizumab (Fasenra)

All of the following are causes of Anemia, except:

a. pregnancy

b. chronic blood loss

c. renal failure

d. hyperlipidemia

e. chemotherapy

f. dietary deficiencies

g. cancers that affect bone marrow

h. all of the above are causes of anemia

d. hyperlipidemia

Which Respiratory Drug has a mechanism of action of: A combination inhaled Anticholinergic and Long Acting Beta-2 specific adrenergic agonist indicated for COPD, BUT NOT Asthma:

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

f. Annoro (Ellipta)

Which Respiratory Drug has a mechanism of action of: A Cholinergic Antagonist that blocks the Parasympathetic mediated Bronchoconstriction.

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

b. Ipratropium (Atrovent)

Which Respiratory Drug has a mechanism of action of: A short acting beta-2 specific inhaled adrenergic agonist

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

e. Albuterol (Proventil)

Which Respiratory Drug has a mechanism of action of: A combination Inhaled Corticosteroid and Beta-2 specific adrenergic agonsist. ( LABA) (2)

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

c. Advair, g. Dulera

Which Respiratory Drug has a mechanism of action of: A Leukotriene Receptor Antagonist (LTRA) that blocks Inflammatory bronchiole constriction

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

a. Montelukast (Singulair)

Which Respiratory Drug has a mechanism of action of: An Inhaled Corticosteroid Asthmatic Drug

a. Montelukast (Singulair)

b. Ipratropium (Atrovent)

c. Advair

d. Fluticasone (Flovent)

e. Albuterol (Proventil)

f. Annoro (Ellipta)

g. Dulera

d. Fluticasone (Flovent)

Which statement about asthma and COPD is FALSE?

a. COPD is almost always associated with a long history of smoking, while asthma occurs in non-smokers as well as smokers

b. COPD symptoms are constant and can get worse over time

c. asthma typically causes acute attacks of wheezing and tightness in your chest

d. COPD symptoms are usually more chronic and can include a cough that brings up phlegm

e. Asthma typically produces symptoms only when triggered by an allergen

f. asthma is typically diagnosed later in life, while COPD is diagnosed in childhood or adolescence

f. asthma is typically diagnosed later in life, while COPD is diagnosed in childhood or adolescence

True or False: No other medications are as effective as Inhaled Corticosteroids (ICS) in the LONG TERM control of asthma in children and adults.

true

All of the following are essential for the maturation of Red Blood Cells and the avoidance of anemia EXCEPT:

a. iron

b. Vitamin B12

c. Vitamin E

d. Folic Acid

c. Vitamin E

What are normal blood values for an adult female?

a. HCT: 47-57%; HGB: 22-26 g/dL

b. HCT: 37-47%; HGB: 12-16 g/dL

c. HCT: 27-37%; HGB: 2-6 g/dL

d. HCT: 12-16%; HGB: 37-47 g/dL

b. HCT: 37-47%; HGB: 12-16 g/dL

Which deficiency is associated with the formation of macrocytes (Megaloblastic Anemia)?

a. Vitamin B12

b. Folic Acid

c. Iron

b. Folic Acid

All of the following are Inhaled Corticosteroids (ICS) + Long Acting Beta-2 Agonist (LABA) combination products EXCEPT:

a. Advair

b. Dulera

c. Anoro Ellipta

d. Symbicort

e. Breo Ellipta

c. Anoro Ellipta

What are the normal blood values for an adult male?

a. HCT: 52-62%; HGB: 24-28 g/dL

b. HCT: 42-52%; HGB: 14-18 g/dL

c. HCT: 22-32%; HGB: 4-8 g/dL

d. HCT: 14-18%; HGB 42-52%

b. HCT: 42-52%; HGB: 14-18 g/dL

All of the following are Inhaled Corticosteroid (ICS's), blocking the bronchoconstriction and mucus production associated with Leukotrienes EXCEPT:

a. Triamcinolone (Azmacort)

b. Ipratropium (Atrovent)

c. Fluticasone (Flovent)

d. Budesonide (Pulmicort)

e. Mometasone Furoate (Asmanex)

b. Ipratropium (Atrovent)

1. Physiologically, bronchial smooth muscle relaxation can be achieved by either a) Cholinergic receptor Antagonism, or b) Beta-2 Adrenergic receptor stimulation on bronchial smooth muscle.

2. In general, in treating asthma, Cholinergic Antagonism of Acetylcholine with Anticholinergic Asthma medications is more effective than drugs that utilize Beta-2 Specific Adrenergic Stimulation on bronchial smooth muscle in achieving bronchodilation.

a. both statements are false

b. the first statement is false, and the second statement is true

c. both statements are true

d. the first statement is true, and the second statement is false

d. the first statement is true, and the second statement is false

True or False: Leukotrienes are inflammatory products of the lipoxygenase pathway from Arachidonic Acid that are responsible for bronchial smooth muscle CONSTRICTION.

true

Respiratory Bronchodilation in treating asthma is achieved via __________ receptor stimulation.

a. Alpha-2 Adrenergic

b. Beta-2 Adrenergic

c. Alpha-1 Adrenergic

d. Beta-1 Adrenergic

b. Beta-2 Adrenergic

Which deficiency is associated with the formation of Pernicious Anemia, that develops from an autoimmune disorder that targets intrinsic factor?

a. folic acid

b. iron

c. Vitamin B12

c. Vitamin B12

All of the following are TRUE with respect to Omalizumab (Xolair) EXCEPT:

a. Omalizumab (Xolair) is a monoclonal antibody drug used in the treatment of asthma

b. Omalizumab (Xolair) is indicated for moderate to persistent asthma in adults and adolescents over 12 years of age

c. Omalizumab (Xolair) binds to Immunoglobulin A (IgA) to limit the release of mediators of the allergic response

d. Omalizumab (Xolair) is an injectavle drug gievn SQ every 2 or 4 weeks

c. Omalizumab (Xolair) binds to Immunoglobulin A (IgA) to limit the release of mediators of the allergic response

Which Drug for Anemia is indicated for neutropenia?

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

Which Drug for Anemia is indicated for Sickle Cell Disease (Increases fetal hemoglobin production)?

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

e. Hydroxyurea (Hydrea)

Which Drug for Anemia is indicated for: A monoclonal antibody drug that targets and binds to the P-Seleltin protein in the blood, minimizing RBC adhesion in Sickle Cell disease and the painful complications associated with blood flow blockages.

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

f. Crizanlizumab (Adakveo)

Which Drug for Anemia is indicated forpernicious anemia?

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

c. Vitamin B12 (Cyanocobalamin)

Which Drug for Anemia is indicated for megaloblastic anemia?

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

b. Folic Acid

Which Drug for Anemia is indicated for iron deficient anemia?

a. Ferrous Sulfate

b. Folic Acid

c. Vitamin B12 (Cyanocobalamin)

d. Filgrastim (Neupogen) and Pegfilgrastim (Neulasta)

e. Hydroxyurea (Hydrea)

f. Crizanlizumab (Adakveo)

a. Ferrous Sulfate

True or False: Inhaled Beta-2 Specific Adrenergic Agonists are the drugs of first choice in patients with any degree of persistent asthma (mild, moderate, or severe).

false

#1 Neutropenia is associated with chemotherapy and bone marrow transplantation. 

#2. Granulocyte Colony Stimulating Factor Drugs are used prophylactically to stimulate granuloctyes production in the bone marrow and reduce the risk of neutropenia. 

a. both statements are false

b. first statement is false, second statement is true

c. first statement is true, second statement is false

d. both statements are true

d. both statements are true

With Hemoglobin (Hgb) and Hematocrit (Hct) reflecting the concentration of oxygen-carrying protein and the volume percentage of red blood cells (RBCs) in blood, the ratio of Hgb to HCT is:

a. HCT = 2 x HGB

b. HGB = 3 x HCT

c. HCT = 3 x HGB

d. HCT = 4 x HGB

c. HCT = 3 x HGB