Aspirin (Bayer) Lecture Notes

Comprehensive vocabulary flashcards covering the pharmacology, administration, nursing considerations, and safety profile of aspirin based on the provided ATI medication guide.

Aspirin Pharmacological Classifications

NSAID, salicylate, antiplatelet agent, and antipyretic.

Mechanism: Prostaglandin Inhibition

The process of inhibiting prostaglandin production to reduce inflammation and fever and to produce analgesia.

Mechanism: Platelet Aggregation

Aspirin reduces this process to provide primary and secondary prevention of cardiovascular events such as MI and ischemic stroke.

Manifestations of Salicylate Toxicity

Key assessment findings including headaches, tinnitus, hyperventilation, and confusion.

Aspirin Administration Volume

Aspirin should be administered with $240\,mL$ ($8\,oz$) of water and food.

Post-Administration Positioning

Instruct clients to remain upright for $15$ to $30$ minutes after taking the medication.

Aspirin Surgery Protocol

Discontinue use $1$ week before elective surgery to manage bleeding risk.

Enteric-Coated Tablet Instruction

Do not crush or chew these specific PO formulations of aspirin.

Common Side Effects of Aspirin

Nausea, epigastric distress, dyspepsia, and gastrointestinal upset.

DRESS

Drug reaction with eosinophilia and systemic symptoms; a potential hypersensitivity adverse effect.

Reye Syndrome

A condition characterized by swelling of the brain and liver damage in children taking aspirin; it is the reason aspirin is contraindicated in the pediatric population.

TTP

Thrombotic thrombocytopenic purpura; a potential adverse effect of aspirin therapy.

Aspirin and Anticoagulant Interaction

Concurrent use with warfarin or heparin increases the risk of bleeding.

NSAID Interaction with Low-Dose Aspirin

Taking other NSAIDs can lead to the decreased effects of low-dose aspirin.

Aspirin Contraindications

Salicylate allergy, bleeding disorders, pediatric population, peptic ulcer disease, gastritis, hemophilia, ibuprofen allergy, and asthma.

Client Teaching: Gastrointestinal Bleeding

Instruct clients to report the onset of black, tarry stools or unexpected bruising.

Aspirin Medication Outcomes

Decreased pain level, fever reduction, decreased joint swelling, and prevention of myocardial infarction and stroke.