Genetics Final

molecular cloning

restriction enzymes

vector

plasmid

insert

ligation

selectable markers

screen vs selection

PCR

transformation

gel electrophoresis

drosophila melanogaster

yeast

alternation of generations (yeast)

can either be haploid or diploid

genetic redundancy

essential genes

genetic modifiers

synthetic lethal mutations

linkage analysis with balancer mutations (fly lab)

genetic mapping by recombination

imprinting

dosage compensation

haplo-insufficient genes

genetic mosaic

synteny

or

ortholog

paralog

semi-dominance

co-dominance

allelic series

hierarchy of dominance

DNA methylation

gene silencing

recombination

dihybrid cross

genetic mapping

map units

double cross-over

quantitative traits

pedigrees

inheritance pattern

punnett squares

probability calculation

dosage compensation mechanisms

genetic mosaic

x-inactivation

mechanism of x-inactivation

aneuploidy

trisomy

nondisjunction

translocation

inverstion

chorionic villus sampling

amniocentesis

karyotype

SKY/FISH

unequal crossing over

non-homologous recombination

haploinsufficiency

complementation test

linkage

haplotypes

forward genetics

reverse genetics

completmentation test

3-point test cross

genetic mapping

chi-square test

recombination rate

epistasis

epistasis

SRY

D

DAX1

sox9

wnt4

cross-inhibition

how to read a genetic pathway figure

Turner syndrome

Klinefelter syndrome

Gender and sex

intersex

indels

point mutations

polymorphism/% polymorphic loci

allele frequency

PCR and RFLP Analysis for genetic diagnostics

homologs

homozygosity

heterozygosity

haplotype length

principle component analysis

SNPs

TAG SNPs

GWAS (Genome Wide Association Studies)

Microsatellite loci

Methods of assessing diversity

• cluster analysis

• principle components analysis

• pie charts of haplotype frequency

founder effect

natural selection

heterozygote advantage

PAN genome