General Pathology Lecture 72: Benign Bone Tumors

What is the singular, slow growing, and painless benign tumor of bone?

Osteoma

On what surface of bone are osteomas usually on?

Peripheral

What are the three main features of Gardner Syndrome?

1. Multiple osteomas

2. Supernumerary teeth

3. Colorectal polyps

What cancer has increased risk in Gardner Syndrome?

Colorectal cancer

What should you ask a Gardner Syndrome patient for in case of referral for a colonoscopy?

Rectal bleeding

Are osteoid osteomas more common with males or females?

Males

What are the two most common sites for osteoid osteomas?

1. Femur

2. Tibia

What is the main feature of osteoid osteomas?

Painful

What is the treatment method for osteoid osteomas?

Radiofrequency ablation

What is the larger version of osteoid osteoma called?

Osteoblastoma

What is the most common site of osteoblastomas?

Vertebrae

What is the treatment method for osteoblastomas?

Surgical excision

What is the carrtilage-covered benign tumor with bony stalk?

Osteochondroma

What causes pain with osteochondromas?

Nerve impingement

What are the three appearances of the condyle with osteochondromas?

1. Asymmetry

2. Malocclusion

3. Enlarged left condyle

What syndrome has the presence of numerous osteochondromas?

Multiple hereditary exostoses syndrome

How could multiple hereditary exostoses syndrome lead to dwarfism?

Lateral displacement of growth plate

What is the main complication of multiple hereditary exostoses syndrome?

Chondrosarcoma (5 - 20%)

What is the benign, locally aggressive, potentially malignant neoplasm of bone?

Giant Cell Tumor

What is the main site of giant cell tumors?

Long bones

What is the recurrence rate of giant cell tumors?

40 - 60%

What is the main metastasis site for giant cell tumors?

Lungs

What could metastasized giant cell tumors undergo?

Spontaneous regression

What is the histological appearance of giant cell tumors?

Multinucleated giant cells