Antipsychotic & Related Medication Study Guide

A comprehensive collection of vocabulary-style flashcards covering FDA indications, side effects, monitoring, and high-yield pearls for antipsychotic medications.

Aripiprazole (Abilify)

An antipsychotic indicated for Schizophrenia, Bipolar I disorder, Adjunctive MDD, Autism irritability, and Tourette disorder; associated with impulse control disorders.

Aripiprazole Side Effects

Common side effects including akathisia, insomnia, anxiety, nausea, and headache.

Brexpiprazole (Rexulti)

Indicated for Schizophrenia, adjunctive MDD, and agitation in Alzheimer’s dementia; serious adverse effects include NMS, TD, and metabolic syndrome.

Chlorpromazine (Thorazine)

Indicated for Schizophrenia, severe nausea/vomiting, and hiccups; one of the most sedating medications.

Chlorpromazine Serious Adverse Effects

QT prolongation, agranulocytosis, cholestatic jaundice, and NMS.

Clozapine (Clozaril)

Used for treatment-resistant schizophrenia and suicidality reduction; requires ANC/CBC monitoring for agranulocytosis.

Clozapine Metabolism

Smoking lowers drug levels, while fluvoxamine increases levels.

Clozapine High-Yield Facts

Associated with agranulocytosis, myocarditis, drooling, and high metabolic risk.

Haloperidol (Haldol)

Indicated for Schizophrenia, acute psychosis, and agitation; has the highest EPS risk.

Lurasidone (Latuda)

Indicated for Schizophrenia and bipolar depression; must be taken with at least 350 calories.

Olanzapine (Zyprexa)

Indicated for Schizophrenia, bipolar disorder, and treatment-resistant depression; smoking lowers drug levels.

Paliperidone (Invega)

Indicated for Schizophrenia and schizoaffective disorder; associated with high prolactin elevation.

Quetiapine (Seroquel)

Indicated for Schizophrenia, bipolar disorder, and adjunct MDD; has high metabolic risk and is highly sedating.

Risperidone (Risperdal)

Indicated for Schizophrenia, bipolar mania, and autism irritability; associated with hyperprolactinemia and EPS.

Xanomeline/Trospium (Cobenfy)

A muscarinic-based schizophrenia medication; adverse effects include urinary retention, tachycardia, and glaucoma risk.

Highest EPS Risk Medications

Haloperidol and Perphenazine.

Highest Metabolic Risk Medications

Olanzapine, Clozapine, and Quetiapine.

Highest Prolactin Elevation Medications

Risperidone and Paliperidone.

Most Sedating Antipsychotics

Chlorpromazine, Quetiapine, Olanzapine, and Clozapine.

Deutetrabenazine

Medication used to treat tardive dyskinesia.