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What is external respiration (1)
Gas exchanges in lungs
Between air (alveoli) and plasma (pulmonary capillaries)
How does oxygen diffuse into blood [ER] (2)
Happens in pulmonary capillaries
Less O2 in capillaries than in alveoli
Diffuses from air → blood
How does altitude affect oxygen diffusion [ER] (2)
Lower atmospheric pressure → less O2
Less O2 in air → can’t diffuse fast enough into blood
How does CO2 diffuse into the lungs [ER] (3)
In pulmonary capillaries
More CO2 in capillaries than in alveoli
CO2 = blood → air
3 ways
Directly from plasma → air (9%)
Carried in body as HbCO2 (27%)
Carried as HCO3 (64%)
What is internal respiration (1)
Exchange of O2 + CO2 between blood + tissue fluid
How does oxygen diffuse into tissues (2)
Cells use up O2 for cellular respiration → low O2 in tissues
More O2 in RBC than tissues
Diffuses from blood → tissues
How does CO2 diffuse into blood (3) [3]
Cells constantly make CO2 → high CO2 in tissue
More CO2 in tissues than RBC
Diffuses from tissues → blood
3 ways
Directly into plasma
Binds to Hb make HbCO2
Makes H2CO3 from CO2 and H2O
HCO3 + H+ → H2CO3 → H2O + CO2 [ER] (3)
HCO3 (plasma) + H+ (RBC) gets catalyzed by carbonic anhydrase
Makes H2CO3 → H2O + CO2
CO2 diffuses into alveoli
HHb → H+ + Hb [ER] (3)
Dissociates at lungs
Gives H+ to HCO3 → H2O
Hb now free to bind w/ O2
HbCO2 → Hb + CO2 [ER] (2)
CO2 in RBC diffuses from pulmonary capillaries → alveoli
Exits out of lungs when exhale
HHb + O2 → HbO2 + H+ [ER] (2)
O2 (alveoli) binds w/ heme
Makes oxyhemoglobin
Oxygenated blood
HbO2 → Hb + O2 [IR] (3)
HbO2 reaches tissues
Dissociates and O2 enters tissues
Hb = deoxygenated
Hb + CO2 → HbCO2 [IR] (2)
CO2 (tissue) diffuse into RBC
Binds w/ Hb
H+ + Hb → HHb [IR] (2)
H+ from production of HCO3 binds to Hb
Maintains pH eqm
CO2 + H2O → H2CO3 → H+ + HCO3 [IR] (3)
Reacts w/ water in plasma
Turns into carbonic A. → dissociates into products
CO2 now transported as HCO3
Why is oxyhemoglobin important (1)
Stops saturation of O2 in blood
O2 can keep diffusing into blood