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Anatomy
study of biological form of an organism
Physiology
study of biological functions an organism performs
Comparative study of animals reveals
s form and function closely correlated
Animal form and function are correlated at __ levels of organization
all
__ affect the way an animal interacts with its environment
Size and shape
Many different animal body plans have evolved and determined by __
genome
__ constrain strength, diffusion, movement, and heat exchange
Physical laws
As animals increase in size, __ must be proportionately larger to support their mass
skeletons
__ reflects different speciesā adaptations to a similar environmental challenge
Evolutionary convergence
Rate of exchange __ to cellās surface area
proportional
Amount of exchanged material __ to a cellās volume
proportional
Materials such as__ , __ , __must be exchanged across animal cell membranes
nutrients, waste products, and gases
Internal exchange surfaces of complex animals

Hierarchical Organization of Body Plans
ļ” Most animals composed of specialized cells organized into tissues that have different functions
ļ” Tissues make up organs, which together make up organ systems
ļ” Some organs, such as the pancreas, belong to more than one organ system
Organ Systems in Mammals

Structure and Function in Animal Tissues
ļ” Different tissues have different structures suited to their functions
ļ” Tissues classified into four main categories:
ļ” Epithelial ļ” Connective ļ” Muscle ļ” Nervous
Epithelial Tissue
ļ” Epithelial tissue covers outside of body and lines organs and cavities within body
ļ” Contains cells that are closely joined
ļ” Shape of epithelial cells may be
ļ” cuboidal (like dice)
ļ” columnar (like bricks on end)
ļ” squamous (like floor tiles)
ļ” The arrangement of epithelial cells may be
ļ” simple (single cell layer)
ļ” stratified (multiple tiers of cells)
ļ” pseudostratified (a single layer of cells of varying length)

Connective Tissue
ļ” Connective tissue mainly binds and supports other tissues
ļ” Contains sparsely packed cells scattered throughout extracellular matrix
ļ” Matrix consists of fibres in a liquid, jellylike, or solid foundation
ļ” Three types of connective tissue fibre, all made of protein:
ļ” Collagenous fibres provide strength and flexibility
ļ” Elastic fibres stretch and snap back to their original length
ļ” Reticular fibres join connective tissue to adjacent tissues
ļ” Connective tissue contains cells, including
ļ” Fibroblasts that secrete the protein of extracellular fibres
ļ” Macrophages that are involved in the immune system
Fibroblasts
secrete the protein of extracellular fibres
Macrophages
are involved in the immune system
Connective Tissue in vertebrates
ļ” In vertebrates, the fibres and foundation combine to form six major types of connective tissue:
1. Loose connective tissue binds epithelia to underlying tissues and holds organs in place
2. Cartilage a strong and flexible support material
3. Fibrous connective tissue found in tendons, which attach muscles to bones, and ligaments, which connect bones at joints
4. Adipose tissue stores fat for insulation and fuel
5. Blood composed of blood cells and cell fragments in blood plasma
6. Bone mineralized and forms the skeleton
Muscle Tissue
ļ” Muscle tissue consists of long cells called muscle fibres, which contract in response to nerve signals ā'
ļ” It is divided in the vertebrate body into three types
1. Skeletal muscle, or striated muscle, responsible for voluntary movement
2. Smooth muscle responsible for involuntary body activities
3. Cardiac muscle responsible for contraction of the heart

Nervous Tissue
ļ” Nervous tissue senses stimuli and transmits signals throughout the animal
ļ” Nervous tissue contains
ļ” Neurons, or nerve cells, that transmit nerve impulses
ļ” Glial cells, or glia, that help nourish, insulate, and replenish neurons
Coordination and Control
ļ” Control and coordination within a body depends on the endocrine system and the nervous system
ļ” Endocrine system transmits chemical signals called hormones to receptive cells throughout body via blood
ļ” A hormone may affect one or more regions throughout body
ļ” Hormones relatively slow acting, but can have long-lasting effects
ļ” Nervous system transmits information between specific locations
ļ” Information conveyed depends on a signalās pathway, not the type of signal
ļ” Nerve signal transmission very fast
ļ” Nerve impulses can be received by neurons, muscle cells, endocrine cells, and exocrine cells
Animals manage their internal environment by __ or __to the external environment
regulating , conforming
Regulating and Conforming
Animals may regulate some environmental variables while conforming to others
aquatic temperature regulators and aquatic temperature conformers
Regulators
use internal control mechanisms to moderate internal change in face of external, environmental fluctuation
Conformer
allow internal condition to vary with certain external changes
Homeostasis
ļ” maintain a āsteady stateā or internal balance regardless of external environment
ļ” In humans, body temperature, blood pH, and glucose concentration are each maintained at a constant level
ļ” For a given variable, fluctuations above or below a set point serve as a stimulus; these are detected by a sensor and trigger a response
ļ” The response returns the variable to the set point
Feedback Control in Homeostasis
ļ” Dynamic equilibrium of homeostasis maintained by negative feedback, returns variable to normal range '
ļ” Most homeostatic control systems function by negative feedback, where buildup of end product shuts system off
ļ” Positive feedback amplifies a stimulus and does not usually contribute to homeostasis in animals
Alterations in Homeostasis
ļ” Set points and normal ranges can change with age or show cyclic variation
ļ”Homeostasis can adjust to changes in external environment, a process called acclimatization
Human circadian rhythm
ļ” Circadian rhythm governs physiological changes that occur roughly every 24 hours
ļ” Occurs in other animals and plants
Homeostatic processes for thermoregulation involve form, function, and behaviour
Thermoregulation
Endothermic animals generate heat by metabolism
ļ” Birds and mammals are endotherms
ļ” Ectothermic animals gain heat from external sources
ļ” Ectotherms include most invertebrates, fishes, amphibians, and nonavian reptiles
Thermoregulation
is process by which animals maintain an internal temperature within a tolerable range
Endothermic animals
generate heat by metabolism
Ectothermic animals
gain heat from external sources
Endothermy and Ectothermy
ļ” In general, endotherms active at a greater range of external temperatures
ļ” While, ectotherms tolerate greater variation in internal temperature
ļ” Endothermy more energetically expensive than ectothermy
Balancing Heat Loss and Gain
ļ” Organisms exchange heat by four physical processes: radiation, evaporation, convection, and conduction
Heat regulation
ļ” Heat regulation in mammals often involves integumentary system: skin, hair, and nails
ļ” Five adaptations help animals thermoregulate:
ļ” Insulation
ļ” Circulatory adaptations
ļ” Cooling by evaporative heat loss
ļ” Behavioural responses
ļ” Adjusting metabolic heat production
Insulation
ļ” Skin, feathers, fur, and blubber reduce heat flow between animal andenvironment
ļ” Insulation especially important in marine mammals such as whales andwalruses
Circulatory Adaptations
ļ” Regulation of blood flow near body surface significantly affects thermoregulation
ļ” Many endotherms and some ectotherms can alter amount of blood flowing between body core and skin
ļ” In vasodilation, blood flow in skin increases, facilitating heat loss
ļ” In vasoconstriction, blood flow in skin decreases, lowering heat loss
Cooling by Evaporative Heat Loss
ļ” Many types of animals lose heat through evaporation of water from their skin
ļ” Panting increases the cooling effect in birds and many mammals
ļ” Sweating or bathing moistens the skin, helping to cool an animal down
Behavioural Responses
ļ” Both endotherms and ectotherms use behavioural responses to control body temperature
ļ” Some terrestrial invertebrates have postures that minimize or maximize absorption of solar heat
Adjusting Metabolic Heat Production
ļ” Thermogenesis is adjustment of metabolic heat production to maintain body temperature
ļ” Thermogenesis increased by muscle activity such as moving or shivering
ļ” Non shivering thermogenesis takes place when hormones cause mitochondria to increase their metabolic activity
Acclimatization in Thermoregulation
ļ” Birds and mammals can vary their insulation to acclimatize to seasonal temperature changes
ļ” When temperatures subzero, some ectotherms produce āantifreezeā compounds to prevent ice formation in their cells
The thermostatic function of the hypothalamus in human thermoregulation
Physiological Thermostats and Fever
ļ” Thermoregulation controlled by a region of the brain called the hypothalamus
ļ” The hypothalamus triggers heat loss or heat generating mechanisms
ļ” Fever is the result of a change to the set point for a biological thermostat
Bioenergetics
ļ” Bioenergetics is the overall flow and transformation of energy in an animal
ļ” Determines how much food an animal needs
ļ” Relates to an animalās size, activity, and environment
Energy Allocation and Use
ļ” After the needs of staying alive met, remaining food molecules can be used in biosynthesis
ļ” Biosynthesis includes
ļ” body growth and repair
ļ” synthesis of storage material such as fat
ļ” production of gametes
Metabolic rate
ļ” Metabolic rate is amount of energy an animal uses in a unit of time
ļ” Metabolic rate can be determined by
ļ” An animalās heat loss
ļ” The amount of oxygen consumed or carbon dioxide produced
Minimum Metabolic Rate and Thermoregulation
Basal metabolic rate (BMR)
Standard metabolic rate (SMR)
ļ” Both rates assume a nongrowing, fasting, and nonstressed animal
Basal metabolic rate (BMR)
the metabolic rate of an endotherm at rest at a ācomfortableā temperature
Standard metabolic rate (SMR)
the metabolic rate of an ectotherm at rest at a specific temperature
Influences on Metabolic Rate
ļ” Ectotherms have much lower metabolic rates than endotherms of a comparable size
ļ” Metabolic rates affected by many other factors. Two of these factors are size and activity
Size and Metabolic Rate
ļ” Metabolic rate proportional to body mass to power of three quarters (m3/4)
ļ” Smaller animals have higher metabolic rates per gram than larger animals
ļ” The higher metabolic rate of smaller animals leads to a higher oxygen delivery rate, breathing rate, heart rate, and greater (relative) blood volume, compared with a larger animal
ļ” The relationship of metabolic rate to body size in mammals
Torpor
physiological state in which activity low and metabolism decreases
Hibernation
a long-term torpor, an adaptation to winter cold and food scarcity
Torpor and Energy Conservation
ļ” Torpor enables animals to save energy while avoiding difficult and dangerous conditions
ļ” Summer torpor, called estivation, enables animals to survive long periods of high temperatures and scarce water
ļ” Daily torpor exhibited by many small mammals and birds and seems adapted to feeding patterns