Lesson 12.3. Class II Anti-Arrythmitic Drugs

beta blockers

Class II Anti-Arrythmitic Drugs are a._____________ except b.___________

a = ?

sotalol

Class II Anti-Arrythmitic Drugs are a._____________ except b.___________

b = ?

𝛽-adrenoreceptor

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

a = ?

cAMP

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

b = ?

Na + and Ca +2

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

c = ?

abnormal pacemakers

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

d = ?

AV node

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

e = ?

PR

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

f = ?

local anesthetic

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

g = ?

chronic HF

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

h = ?

fatal arrhythmias

CLASS II MOA

• Blocks a.______________ and reduction of b._______ → reduction of c.__________________ currents and suppression of d._________________

• e.___________ is sensitive to Class II

• f._____ interval is prolonged

• Exhibits some extent of direct g._______________ (rare) effect on the heart (Na + -channel blocking)

• Reduces progression of h.________ and incidence of potentially i.___________

i = ?

Bronchospasm

CLASS II ADR

1. (fatal) - most drugs are non-selective, so it can also affect the β2 receptors of the lungs

2. slows heartbeat, β-blockers are (-) chronotropic

3. CNS ______________

4. ________ disturbances

5. other effect/s

1 = ?

Heart Failure

CLASS II ADR

1. (fatal) - most drugs are non-selective, so it can also affect the β2 receptors of the lungs

2. slows heartbeat, β-blockers are (-) chronotropic

3. CNS ______________

4. ________ disturbances

5. other effect/s

2 = ?

lethargy

CLASS II ADR

1. (fatal) - most drugs are non-selective, so it can also affect the β2 receptors of the lungs

2. slows heartbeat, β-blockers are (-) chronotropic

3. CNS ______________

4. ________ disturbances

5. other effect/s

5 = ?

Sotalol

CLASS II

• Generally classified under Class III, but has Class II actions

Esmolol

CLASS II

• Exclusively used for acute arrhythmias

Propranolol, Nadolol, Metoprolol, and Timolol

CLASS II

• Used chronically to prevent arrhythmias in patients with a history of myocardial infarction