Hematology WBC Morphology Identification

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Last updated 6:50 PM on 4/15/26
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19 Terms

1
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Auer Rods

- Needle-shaped rods

- Red-purple inclusions

- Found in leukemic myeloblasts & promyelocytes

- Made of fused lysosomes, peroxidase and lysosomal enzymes

<p>- Needle-shaped rods</p><p>- Red-purple inclusions</p><p>- Found in leukemic myeloblasts &amp; promyelocytes</p><p>- Made of fused lysosomes, peroxidase and lysosomal enzymes</p>
2
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Banded Neutrophil

- Indented nucleus >50% w/o filament

- Coarse, clumped chromatin

- Pale pink cytoplasm

- Secondary granules

- 1:2 N:C ratio

<p>- Indented nucleus &gt;50% w/o filament</p><p>- Coarse, clumped chromatin</p><p>- Pale pink cytoplasm</p><p>- Secondary granules</p><p>- 1:2 N:C ratio</p>
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Basophil

- Clumped chromatin, no nucleoli

- 1:2 - 1:3 N:C ratio

- Segmented nucleus, obscured by granules

- Large, blue-black, purple-red granules

<p>- Clumped chromatin, no nucleoli</p><p>- 1:2 - 1:3 N:C ratio</p><p>- Segmented nucleus, obscured by granules</p><p>- Large, blue-black, purple-red granules</p>
4
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Blast

- Round or oval nucleus

- Finely, reticulated chromatin

- 3-5 large nucleoli, can be single, large, & centrally located

- Scant, dark-blue cytoplasm w/ no granules

- 7:1-5:1 N:C ratio

<p>- Round or oval nucleus</p><p>- Finely, reticulated chromatin</p><p>- 3-5 large nucleoli, can be single, large, &amp; centrally located</p><p>- Scant, dark-blue cytoplasm w/ no granules</p><p>- 7:1-5:1 N:C ratio</p>
5
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Dohle Bodies

- Gray-blue, variable-shaped inclusions in cytoplasm

<p>- Gray-blue, variable-shaped inclusions in cytoplasm</p>
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Eosinophil

- 1:3 N:C ratio

- Clumped chromatin, no nucleoli

- Large, orange-red granules

<p>- 1:3 N:C ratio</p><p>- Clumped chromatin, no nucleoli</p><p>- Large, orange-red granules</p>
7
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Hypersegmented Neutrophil

- Neutrophils with 5 or more lobed nuclei

<p>- Neutrophils with 5 or more lobed nuclei</p>
8
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Lymphocyte

- Round to ovoid nucleus

- Dense, clumpy, condensed chromatin

- 5:1-2:1 N:C ratio

- Scant amounts of pale blue to moderately basophilic cytoplasm

<p>- Round to ovoid nucleus</p><p>- Dense, clumpy, condensed chromatin</p><p>- 5:1-2:1 N:C ratio</p><p>- Scant amounts of pale blue to moderately basophilic cytoplasm</p>
9
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Metamyelocyte

- Indented <50% Nucleus

- Moderately clumped cytoplasm

- Pale pink to cream-colored cytoplasm

- Secondary granules

- 1.5:1 - 1:1 N:C Ratio

<p>- Indented &lt;50% Nucleus</p><p>- Moderately clumped cytoplasm</p><p>- Pale pink to cream-colored cytoplasm</p><p>- Secondary granules</p><p>- 1.5:1 - 1:1 N:C Ratio</p>
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Myelocyte

- Round to oval nucleus

- Coarse chromatin

- Slight blue to cream-colored cytoplasm

- Primary & secondary granules

- 2:1 N:C Ratio

<p>- Round to oval nucleus</p><p>- Coarse chromatin</p><p>- Slight blue to cream-colored cytoplasm</p><p>- Primary &amp; secondary granules</p><p>- 2:1 N:C Ratio</p>
11
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Monocyte

- Horseshoe-shaped, indented

- Round to oval nucleus

- Nuclear folding sometimes

- Vacuoles present

- Lacy chromatin

- Gray, gray-blue, ground glass appearance

- Fine, pale pink, dust-like granules evenly dispersed

- 4:2-2:1 N:C ratio

<p>- Horseshoe-shaped, indented</p><p>- Round to oval nucleus</p><p>- Nuclear folding sometimes</p><p>- Vacuoles present</p><p>- Lacy chromatin</p><p>- Gray, gray-blue, ground glass appearance</p><p>- Fine, pale pink, dust-like granules evenly dispersed</p><p>- 4:2-2:1 N:C ratio</p>
12
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Plasma Cell

- Round, ovoid eccentric nucleus

- Clumped chromatin, no nucleoli

- Abundant, deep-blue cytoplasm w/ clear area next to nucleus

- 1:2 N:C ratio

<p>- Round, ovoid eccentric nucleus</p><p>- Clumped chromatin, no nucleoli</p><p>- Abundant, deep-blue cytoplasm w/ clear area next to nucleus</p><p>- 1:2 N:C ratio</p>
13
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Pelger-Huët Cell (Hyposegmented Neutrophil)

- Peanut-shaped, bilobed, or non-segmented granulocyte

<p>- Peanut-shaped, bilobed, or non-segmented granulocyte</p>
14
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Promyelocyte

- Fine, slightly coarse chromatin

- Basophilic cytoplasm

- Round to oval nucleus

- 1-3+ nucleoli present

- Auer rods may be present

<p>- Fine, slightly coarse chromatin</p><p>- Basophilic cytoplasm</p><p>- Round to oval nucleus</p><p>- 1-3+ nucleoli present</p><p>- Auer rods may be present</p>
15
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Pyknotic Cell

- Degenerating cells

- Variable nuclear shape

- Multiple lobes, varying in size and shape w/o connecting filaments

- Dark, homogenous, dense chromatin

<p>- Degenerating cells</p><p>- Variable nuclear shape</p><p>- Multiple lobes, varying in size and shape w/o connecting filaments</p><p>- Dark, homogenous, dense chromatin</p>
16
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Reactive Lymphocyte

- Pleomorphic

- Easily indented by surrounding cells

- Irregular nucleus

- Occasional nucleoli

- Coarse to fine & dispersed chromatin

- Can have vacuoles or azurophilic granules

<p>- Pleomorphic</p><p>- Easily indented by surrounding cells</p><p>- Irregular nucleus</p><p>- Occasional nucleoli</p><p>- Coarse to fine &amp; dispersed chromatin</p><p>- Can have vacuoles or azurophilic granules</p>
17
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Segmented Neutrophil

- Highly condensed nuclear chromatin

- Segmented/lobated nucleus (3-5 lobes)

- Connected by thin filament

- Pale, pink cytoplasm

- 1:3 N:C ratio

<p>- Highly condensed nuclear chromatin</p><p>- Segmented/lobated nucleus (3-5 lobes)</p><p>- Connected by thin filament</p><p>- Pale, pink cytoplasm</p><p>- 1:3 N:C ratio</p>
18
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Toxic Granulation

- Dark purple-black primary granules in cytoplasm of neutrophils

<p>- Dark purple-black primary granules in cytoplasm of neutrophils</p>
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Vacuolated Neutrophil w/ Toxic Granulation

- Unstained circular area within cytoplasm

- Associated with bacterial or fungal infections when seen with neutrophils

<p>- Unstained circular area within cytoplasm</p><p>- Associated with bacterial or fungal infections when seen with neutrophils</p>