(5) Antibacterials V (Intro To Antimicrobial Resistance Mechanism)

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Last updated 10:26 PM on 4/11/26
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4 Terms

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Main resistance mechanisms:

  1. antibiotic-inactivating enzymes

    • β-lactamases

  2. altered targets

    • PBP2a

    • D-Ala-D-Lac

  3. reduced accumulation

    • efflux pumps

2
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Important concept

  • Gram-positive:

    • no outer membrane

    • β-lactamase released into environment

  • Gram-negative:

    • extra membrane changes resistance dynamics

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