IMMUNITY 2

Autograft

transplant from your own body

Allograft

same species

xenograft

different species

Isograft

identical twins

How can you maximize transplants

• mhc/mla match

• living donor

• constant bloodflow

• avascular tissue

• immunosuppresants

what are considerastions w infant transplants

• dont respond as badx to forgein tissue

• can have <ideal MHC match

• lower supply of organs

Specific Immunity

• T+B cells

• specific antibodies

• fast

Non-Specific Immunity

• first line of defense

• lymphocytes: neutrophils, macrophages, NK cells

• slow

What are the cons of immunospressants

can allow for opportunistic infx, kidney damage

Where is the antibody IGg found?

blood

What does the antibody IGe do?

Allergic response, releases histamine

Where are Iga antibodies found

tears, mucuos

What do Igm antibodies do

attack foreign red blood cells in host

what is natural active immunity

immunity from experiencing a disease

what is artificial active immunity

vaccines

what is natural passive immunity

inheiritied from mother

What is artificial passive immunity

antibody trahnsplant (ex: anti-venom)

Indirect Coombs (IAT) test

detects free-floating antibodies in the blood that could potentially attack rbcs

Titer test

measure concentration nof specific antibodies in the blood

ELISA test

detects antibodies/antigens using enzymes (color change)

MHC (HLA) test

tissue type by protein markers on WBCs

What is GVHD

When donor t cells attack the host. presents with diharea, rashes, jaundice.