IN CLASS counter current multiplication

in the collecting duct you have receptors for what

ADH on basolateral membrane

in the collecting duct you have what on the apical membrane

AQP2

in the collecting duct you have what on the basolateral membrane

AQP3 or 4

in the collecting duct you have in the deep part…

urea transporters

the urea transporter: UT-A1 on the collecting duct are on the

apical membrane

the urea channel always on the basolateral membrane of the collecting duct and is only present if UT-A1 is there is…..

UT-A3

you want urea transporter and h2o channel at same time because….

if urea is moving across membrane into blood we reabsorb more h2o

diabetes insipidus is a condition caused by inability to secret ADH. what symptoms would they have

dilute urine and constant thirst

pct dct and capsule is all in the

cortex

loop of henle and cd are in the

medulla

the peritubular capillaries branch coming off the…

efferent arterial

vasa recta

part of peritubular right next to loop of henle

osmolarity in blood is typically

300 mOsm

when filtrate initially comes in capsule its

300 mOsm

in PCT blood and filtrate are both

300 mOsm

cortex is also

300 mOsm

step 1 of concentrating urine is

equal reabsorption of h2o and solutes

step 2 of concentrating urine is

concentration of blood and dilution of filtrate

step 3 of concentrating urine is

dilution of blood and concentration of filtrate

step 4 of concentrating urine is

ADH dependent concentration of filtrate

the blood goes…

PCT, DCT, and then medulla

the blood concentration as it goes down goes from

300, 600, 900, 1200

the blood concentration as it goes ups the descending limb goes

1200, 900, 600, 300

the medullas concentration goes from

600, 900, 1200