BSCI 331: Exam 3 - Transcription Factor Mechanisms
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6 Terms
chromatin
some TF’s help to unpack chromatin, making gene accessible to RNA polymerase and initiation complex
RNA polymerase and/or general TF to promoter
some TF’s control recruitment of RNA polymerase and/or the general transcription factors to the promoter
regulate “switch”
some TF’s may regulate the switch from initiation to elongation → conformational change
changing chromatin structure
some TF’s help recruit histone-modifying enzymes to change local chromatin structure
long-distance interaction
some TF’s bend DNA to allow long-distance interactions between gene regulatory regions to be closer to promoter in 3D space
can transcription factors serve as activators or repressors?
yes!