PHARM 2 FINAL: Drugs for Neurodegenerative Diseases

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Last updated 7:54 PM on 4/14/26
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6 Terms

1
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Levodopa

MOA: Taken up by dopamine neurons and converted to dopamine

primary indication: Treatment for Parkinson’s disease

side effects/notes: Movement disorders from excess dopamine

2
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Carbidopa

MOA: Structural analog to levodopa; reduces conversion of levodopa to dopamine in peripheral tissues, thereby increases the amount of levodopa that enters the brain

primary indications:Adjunct to Levodopa in treatment of Parkinson’s disease

side effects/notes: Reduces the GI and cardiovascular effects of Levodopa

3
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Bromocriptine

MOA: D2 receptor agonist and D1 receptor antagonist

primary indications: Used as adjunct to Levodopa in patients with advanced Parkinson’s disease

4
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Ropinirole

MOA: D2 receptor agonist

primary indications: Early stages of Parkinson’s disease; restless leg syndrome

5
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Benztropine

MOA: Anticholinergic

primary indications: Adjunctive treatment

side effects/notes: Anticholinergic side effects

6
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Donepezil

MOA: Reversible cholinesterase inhibitor, which increases acetylcholine in the CNS

primary indications: Alzheimer’s disease