Glucogenesis (Reactions different than Glycolysis)

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Last updated 7:06 PM on 4/9/26
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8 Terms

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(2) Pyruvate to Phospoenolpyruvate: Energetically expensive

1st step: Pyruvate to oxaloacetate using pyruvate carboxylase (carboxylation) using 2 ATP (1 per pyruvate molecule)

2nd step: Oxaloacetate to phosphoenolpyruvate using phosphoenolpyruvate carboxykinase (decarboxylation) using 2 GTP (1 per oxcaloacetate molecule)

2
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Fructose 1,6 - biphosphate to Fructose 6 phospate

Fructose 1,6 - biphosphatase-1 removes phosphate group at carbon 1 (no ATP produced)

3
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Glucose 6-phosphate to Glucose

Glucose 6-phosphatase removes a phosphate group at carbon 6

4
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How many H20 molecules used?

6 (trust me bro)

5
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How many Pi produced?

6 (trust me bro)

6
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Why is there no CO2 in net reaction?

Used up and produced cancel each other out

7
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Glycolysis Net Reaction and free energy

Glucose + 2ADP + 2NAD+ + 2Pi —→ 2Pyruvate + 2ATP + 2NADH + 2H+ + 2H2O; -84 kJ/mol

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Gluconeogenesis Net Reaction and Free energy

2Pyruvate + 4ATP + 2GTP + 2NADH + 2H+ + 6H2O —→ Glucose + 4ADP + 2GDP + 2NAD+ + 6 Pi ; -38 kJ/mol