Drug interactions

Chapter 1

antacids

kidney disease

antitussives

glaucoma

laxatives

kidney disease

nasal decongestants

heart disease, high blood pressure, thyroid disease, diabetes,

Nicotine replacements

asthma, depressents, heart disease, irregular heart beat, myocardial infarction

sleeping aids

emphysema, chronic bronchitis, glaucoma,

carbamazepine

increased by erythromycin, clarithromycin, fluconazole

digoxin

increased by quinidine

flouroquinolone

decreased by aluminum-, calcium-, magnesium-, iron containing medications

HMG CoA

increased by erthyromicym, niacin, gemfibrozil, itraonazole

lithium

increased by diurectics and NSAIDs

Morphine

decreased by naloxone

Nitrates

increased PDE5 inhibitors

oral contraceptives

decreased by antibiotics

penicillin

decreased by probenecid

phenobarbial

decreased by phenytoin

SSIs

increased by triptans

TCAs

increased by SSRIs

tetracycline

decreased by ketoconazole

potassium chloride

increased by spironolactone

warfarin

increased by ciprofloxin and clarithromycin and decreased by Vitamin K

cimetidine

decreased antacids

ketoconazole

decreased by antacids

levothyroxine

decreased by iron tablets

tetracylcine

decreased by antacids

warfarin

increased by aspirin, acetaminophen, NSAIDs

black cohosh

estrogens- increase estrogen activity

echinacea

ketoconazole- additive hepatotoxic effect

Garlic

decreases the effects of terazosin

St Johns wort

decreases the effects of warfarin

Grapefruit juice

increase alprazolam, amiodarone, atorvastatin, CCB, carbamazipine, estrogens, HMG CoA, verapamil. Decreased losartan

caffeine

central nervous stimulants

fatty foods

griseofulvin

food

tetracycline

warfarin (food/s)

cranberry juice, broccoli, Brussels sprouts, cabbage, romaine lettuce, spinach