translocations of B cell

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translocations

Last updated 11:44 PM on 5/11/26
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8 Terms

1
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t(14;18)

Follicular lymphoma → BCL2 → blocks apoptosis.

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t(11;14)

Mantle cell lymphoma → Cyclin D1 → pushes cell cycle.

3
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MYC function?

Increases proliferation.

4
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BCL2 function?

Prevents apoptosis.

5
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Cyclin D1 function?

Drives G1→S cell cycle progression.

6
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BCL1 vs BCL2?

BCL1 (Cyclin D1) → Mantle cell lymphoma t9 11,14)→ ↑ cell cycle. BCL2 → Follicular lymphoma and large b cell lymphoma → ↓ apoptosis.

7
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BCL2 prevents apoptosis.

t(14;18) → BCL2 bcl2 body cells live to long follicular lymphoma cells survive too long

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BCR-ABL gene?

t(9;22) Philadelphia chromosome → constitutive non-receptor tyrosine kinase → CML.