foundation of DOMS - 2nd powerpoint

how is DOMS primarily caused

eccentric muscle contractions

what is the microstructure sarcomere damage in DOMS

sarcomere overstretching affecting Zdisks and cytoskeletal issues

what is the role of titin and mechanial amplification

titin stiffens during loading and increases tension and stress

what does the initiation of signaling cascades of stress and sarcolemma disruptions lead to

inflammation

what occurs in muscle cells in calcium overload

eccentric will increase ca to degrade muscle proteins

how is mitochodnrial ROS affected by calcium overload

mitochondira increases ROS and activiating ROS pathways

what occurs with neurocentric mechanisms in DOMS

damage to piezo2 channels that affects stretch reflex

what does piezo1 detect

detects mechanical stretch, shear stress, and tissue stiffness

what does piezo2 detect

principle of transducer for proprioception

what occurs in peripehral sensitization in DOMS: where is pain

pain from muscle nocicpetor not fiber damage

what mediators are involved in inflammation

IL-6, TNF-A, and bradykinin and prostaglandin E2

what two mediators enhance pain

B2 bradykinin and COX2

what is the role of macrophages in DOMS

support repair and inflammation

DOMS involve the coordination of what 4 responses

muscle fibers, connective tissue, immune cells, and sensory neurons