Dendritic Cells and Antigen Presentation
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7 Terms
What connects the innate to the adaptive immune system
Antigen Presentation
What is antigen
Antigen is any substance the causes the body to induce an immune response
List the types of Antigen
Infection
Allergy
Autoimmunity
Injury
Cancer
Outline the steps of antigen presentation
Microbes enter through epithelial barrier
Microbes are captured by antigen presenting cells
Microbes are transported to the peripheral lymphoid organs
Peptide fragments of protein antigens are displayed by APCs on their Major Histocompatibility Compex for recognition by the T cell receptor on the surface of T lymphocytes
What are the two antigen presentation pathway
MHC 1 ( The antigen is internal ) and MHC 2 (phagocytosis of bacterial antigens)
Explain the MHC class 1 presentation
Performed by all nucleated cells
MHC class 1 antigen presentation activates cytotoxic T cells
Explain the MHC class 2 presentation
Performed by APCs
The antigen is external
MHC class 2 antigen presentation activates T helper cells
This is mainly done by dendritic cells