Respiratory drugs

Tessalon generic name?

Benzonatate

Benzonatate brand name(s)?

Tessalon

Benzonatate drug class?

Antitussive

Benzonatate indication(s)?

Cough suppressant

Benzonatate MOA?

reduces the cough reflex by anesthetizing the stretch receptors in respiratory passages

Benzonatate adverse effects?

rare- hypersensitivity reactions, visual hallucinations

Benzonatate renal dose adjustment?

N

Benzonatate hepatic dose adjustment?

N

Proventil / Ventolin / Proair generic name?

Albuterol (inhalation)

Albuterol (inhalation) brand name(s)?

Proventil; Ventolin; Proair

Albuterol (inhalation) drug class?

Beta-2 agonist

Albuterol (inhalation) indication(s)?

Asthma (acute exacerbation therapy); Exercise-induced asthma (preventative therapy)

Albuterol (inhalation) MOA?

stimulates adenyl cyclase which causes the formation of cAMP which causes relaxation of bronchial smooth muscle

Albuterol (inhalation) adverse effects?

Pharyngitis, tachycardia, nervousness, tremor

Albuterol (inhalation) renal dose adjustment?

N

Albuterol (inhalation) hepatic dose adjustment?

N

Flovent generic name?

Fluticasone (Inhalation)

Fluticasone (Inhalation) brand name(s)?

Flovent

Fluticasone (Inhalation) drug class?

Corticosteroid

Fluticasone (Inhalation) indication(s)?

Asthma (maintenance therapy)

Fluticasone (Inhalation) MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory effects

Fluticasone (Inhalation) adverse effects?

pharyngeal candidiasis

Fluticasone (Inhalation) renal dose adjustment?

N

Fluticasone (Inhalation) hepatic dose adjustment?

N

Flonase generic name?

Fluticasone (Nasal)

Fluticasone (Nasal) brand name(s)?

Flonase

Fluticasone (Nasal) drug class?

Corticosteroid

Fluticasone (Nasal) indication(s)?

Rhinitis

Fluticasone (Nasal) MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory, antipruritic, and vasoconstrictive effects

Fluticasone (Nasal) adverse effects?

Nasal burning, epistaxis, pharyngitis

Fluticasone (Nasal) renal dose adjustment?

N

Fluticasone (Nasal) hepatic dose adjustment?

N

Symbicort generic name?

Budesonide/formoterol (inhalation)

Budesonide/formoterol (inhalation) brand name(s)?

Symbicort

Budesonide/formoterol (inhalation) drug class?

Corticosteroid/beta-2 agonist

Budesonide/formoterol (inhalation) indication(s)?

Asthma (maintenance therapy); COPD (maintenance therapy)

Budesonide/formoterol (inhalation) MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory effects/selectively agonizes B2 receptots causing bronchial smooth muscle relaxation

Budesonide/formoterol (inhalation) adverse effects?

URTIs, pharyngeal candidiasis

Budesonide/formoterol (inhalation) renal dose adjustment?

N

Budesonide/formoterol (inhalation) hepatic dose adjustment?

N

Breo Ellipta generic name?

Fluticasone/vilanterol (inhalation)

Fluticasone/vilanterol (inhalation) brand name(s)?

Breo Ellipta

Fluticasone/vilanterol (inhalation) drug class?

Corticosteroid/beta-2 agonist

Fluticasone/vilanterol (inhalation) indication(s)?

Asthma (maintenance therapy); COPD (maintenance therapy)

Fluticasone/vilanterol (inhalation) MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory effects/selectively agonizes B2 receptots causing bronchial smooth muscle relaxation

Fluticasone/vilanterol (inhalation) adverse effects?

URTIs, pharyngeal candidiasis

Fluticasone/vilanterol (inhalation) renal dose adjustment?

N

Fluticasone/vilanterol (inhalation) hepatic dose adjustment?

N

Advair generic name?

Fluticasone/salmeterol (inhalation)

Fluticasone/salmeterol (inhalation) brand name(s)?

Advair

Fluticasone/salmeterol (inhalation) drug class?

Corticosteroid/beta-2 agonist

Fluticasone/salmeterol (inhalation) indication(s)?

Asthma (maintenance therapy); COPD (maintenance therapy)

Fluticasone/salmeterol (inhalation) MOA?

decreases chemical mediators of inflammation by inducing phospholipase A2 (PLA2) inhibitory proteins and inhibiting arachidonic acid release resulting in anti-inflammatory effects/selectively agonizes B2 receptots causing bronchial smooth muscle relaxation

Fluticasone/salmeterol (inhalation) adverse effects?

URTIs, pharyngeal candidiasis

Fluticasone/salmeterol (inhalation) renal dose adjustment?

N

Fluticasone/salmeterol (inhalation) hepatic dose adjustment?

N

Combivent Respimat generic name?

Albuterol/ipratropium (inhalation)

Albuterol/ipratropium (inhalation) brand name(s)?

Combivent Respimat

Albuterol/ipratropium (inhalation) drug class?

Beta-2 agonist/anticholinergic agent

Albuterol/ipratropium (inhalation) indication(s)?

Asthma (acute exacerbation therapy); COPD (acute exacerbation therapy)

Albuterol/ipratropium (inhalation) MOA?

stimulates adenyl cyclase which causes the formation of cAMP which causes relaxation of bronchial smooth muscle/inhibits action of acetylcholine at type 3 muscarinic receptors to cause bronchodilation

Albuterol/ipratropium (inhalation) adverse effects?

Pharyngitis, tachycardia, nervousness, tremor/bronchitis, URTIs

Albuterol/ipratropium (inhalation) renal dose adjustment?

N

Albuterol/ipratropium (inhalation) hepatic dose adjustment?

N

Spiriva generic name?

Tiotropium (inhalation)

Tiotropium (inhalation) brand name(s)?

Spiriva

Tiotropium (inhalation) drug class?

Anticholinergic agent

Tiotropium (inhalation) indication(s)?

COPD (maintenance therapy)

Tiotropium (inhalation) MOA?

inhibits action of acetylcholine at type 3 muscarinic receptors to cause bronchodilation

Tiotropium (inhalation) adverse effects?

bronchitis, URTIs

Tiotropium (inhalation) renal dose adjustment?

N

Tiotropium (inhalation) hepatic dose adjustment?

N

Singulair generic name?

Montelukast

Montelukast brand name(s)?

Singulair

Montelukast drug class?

Leukotreine receptor antagonist

Montelukast indication(s)?

Asthma (maintenance therapy); Seasonal and allergic rhinitis

Montelukast MOA?

inhibits cysteinyl leukotreine receptor to reduce inflammation in the lungs and asthma symptoms

Montelukast adverse effects?

well tolerated, rare- psychiatric disorders

Montelukast renal dose adjustment?

N

Montelukast hepatic dose adjustment?

N

Xyzal generic name?

Levocetirizine

Levocetirizine brand name(s)?

Xyzal

Levocetirizine drug class?

Antihistamine (second generation)

Levocetirizine indication(s)?

Allergic rhinitis; Urticaria

Levocetirizine MOA?

selectively antagonizes peripheral histamine H1-receptors

Levocetirizine adverse effects?

Drowsiness, fatigue, headache

Levocetirizine renal dose adjustment?

Y

Levocetirizine hepatic dose adjustment?

N

Claritin generic name?

Loratadine

Loratadine brand name(s)?

Claritin

Loratadine drug class?

Antihistamine (second generation)

Loratadine indication(s)?

Allergic rhinitis; Urticaria

Loratadine MOA?

selectively antagonizes peripheral histamine H1-receptors

Loratadine adverse effects?

Drowsiness, fatigue, headache

Loratadine renal dose adjustment?

Y

Loratadine hepatic dose adjustment?

N

Atarax / Vistaril generic name?

Hydroxyzine

Hydroxyzine brand name(s)?

Atarax; Vistaril

Hydroxyzine drug class?

First generation antihistamine

Hydroxyzine indication(s)?

Anxiety; Pruritis