Extracellular Matrix

What does the ECM contain?

connective tissue and basal lamina

What is the basal lamina?

basement membrane

What is the basement membrane made of?

sandwich of connective tissue and epithelial cells

What is the ground substance made of?

proteins and sugars - proteoglycans and GAGs

What are proteoglycans?

sugar-based protein

What are GAGs?

repeating sugar units, negatively charged and attract +ions and water, have a gel-like consistency

What is the main shock absorber in out body with examples?

cartilage - jaw, spine, knee

What is the ECM made of?

ground substance, fibrous structual proteins, and adhesion proteins

What are examples of fibrous structural proteins?

collagen and elastin

What are examples of elastin and explain it?

skin and lungs - ratio changes based on structure

How is collagen made?

in surrounding cells to make matrix arouns it, ribosomes in RER are sent to Golgi - made in lumen of protein to be secreted

What are examples of adhesion proteins?

fibronectin and laminin

What is fibronectin?

links components within matrix and ECM to cell surfaces

What is laminin?

can link integrin to cytoskeletin ex: actin, cell attachment to ECM can be stable (permanent) or temporary (transient) ex: blood vessel (injury with WBCs)