DECK 9: Evolution & Enhancers

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Last updated 6:38 PM on 6/17/26
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8 Terms

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Enhancer conservation

Enhancers tend to be conserved but less so than essential coding regions

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Snake ZRS example

Snake-specific sequence changes in an otherwise conserved limb enhancer

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ETS1 motif loss

Specific TF binding site lost in snakes prevents SHH limb expression

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"Serpentized" mice

Mouse ZRS replaced with snake ZRS → limb reduction

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Functional restoration

Restoring the single ETS1 motif rescues full enhancer function

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Key insight

Single regulatory changes can drive major morphological transitions

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Publication

Kvon et al., "Progressive Loss of Function in a Limb Enhancer during Snake Evolution"