Lecture 4: Ribosomal-Inhibiting Antibacterials- summary table

What is the classification of Doxycycline?

Tetracycline

What is the spectrum of Doxycycline?

Gm(+) and Gm(-); Brucella, Chlamydia, rickettsiae, and spirochetes

What formulations are available for Doxycycline?

Oral pill and injectable

What is the trade name for Doxycycline?

Generic

What are the clinical indications for Doxycycline?

L-form bacteria, Lyme disease, brucellosis, chlamydiosis in companion animals; contracted tendons in foals

What is a special consideration for Doxycycline?

Neuroprotective

What is the classification of Gentamicin?

Aminoglycoside

What is the spectrum of Gentamicin?

Gm(-) aerobes and Gm(+) cocci

What formulations are available for Gentamicin?

Injectable; intra-uterine

What is the trade name for Gentamicin?

Generic

What are the clinical indications for Gentamicin?

Gm(-) sepsis in horses; colibacillosis in piglets; metritis in horses

What is a special consideration for Gentamicin?

Nephrotoxic and ototoxic

What is the classification of Amikacin?

Aminoglycoside

What is the spectrum of Amikacin?

Gm(-) aerobes and Gm(+) cocci

What formulation is available for Amikacin?

Injectable

What is the trade name for Amikacin?

Amiglyde

What are the clinical indications for Amikacin?

Used only if dictated by antibiogram

What is a special consideration for Amikacin?

Nephrotoxic and ototoxic

What is the classification of Streptomycin?

Aminoglycoside

What is the spectrum of Streptomycin?

Gm(-) aerobes and Gm(+) cocci

What formulation is available for Streptomycin?

Intramammary

What is the trade name for Streptomycin?

Quartermaster

What are the clinical indications for Streptomycin?

Bovine mastitis (non-lactating)

What is a special consideration for Streptomycin?

Non-toxic due to intramammary route

What is the classification of Clarithromycin?

Macrolide

What is the spectrum of Clarithromycin?

Gm(+) aerobes and all anaerobes

What formulation is available for Clarithromycin?

Injectable

What is the trade name for Clarithromycin?

Generic

What are the clinical indications for Clarithromycin?

Equine rhodococcal infections

What is a special consideration for Clarithromycin?

Combined with rifampin

What is the classification of Azithromycin?

Macrolide

What is the spectrum of Azithromycin?

Gm(+) aerobes, all anaerobes, and Pseudomonas

What formulation is available for Azithromycin?

Oral pill

What are the trade names for Azithromycin?

Z-pack, Zithromax

What are the clinical indications for Azithromycin?

Respiratory infections in cats

What is a special consideration for Azithromycin?

It is awesome!

What is the classification of Tulathromycin?

Macrolide

What is the spectrum of Tulathromycin?

Gm(+) aerobes, all anaerobes, and Mycoplasma

What formulation is available for Tulathromycin?

Long-acting pneumo-concentrating injectable

What are the trade names for Tulathromycin?

Draxxin (generic), Draxxin KP

What are the clinical indications for Tulathromycin?

BRD metaphylaxis, pinkeye, swine respiratory disease; treating BRD

What is a special consideration for Tulathromycin?

May activate motilin receptor → GI hyperperistalsis → anorexia

What is the classification of Gamithromycin?

Macrolide

What is the spectrum of Gamithromycin?

Gm(+) aerobes, all anaerobes, and Mycoplasma

What formulation is available for Gamithromycin?

Long-acting injectable

What is the trade name for Gamithromycin?

Zactran

What are the clinical indications for Gamithromycin?

BRD metaphylaxis

What is a special consideration for Gamithromycin?

May activate motilin receptor → GI hyperperistalsis → anorexia

What is the classification of Tildipirosin?

Macrolide

What is the spectrum of Tildipirosin?

Gm(+) aerobes, all anaerobes, and Mycoplasma

What formulation is available for Tildipirosin?

Long-acting injectable

What is the trade name for Tildipirosin?

Zuprevo

What are the clinical indications for Tildipirosin?

BRD metaphylaxis

What is a special consideration for Tildipirosin?

May activate motilin receptor → GI hyperperistalsis → anorexia

What is the classification of Tilmicosin?

Macrolide

What is the spectrum of Tilmicosin?

Gm(+) aerobes, all anaerobes, and Mycoplasma

What formulations are available for Tilmicosin?

Long-acting injectable (Micotil); feed additive (Pulmotil)

What are the clinical indications for Tilmicosin?

BRD metaphylaxis; swine and poultry respiratory disease

What are the special considerations for Tilmicosin?

Micotil is cardiotoxic; Pulmotil is non-toxic

What is the classification of Tylosin?

Macrolide

What is the spectrum of Tylosin?

Gm(+) aerobes, all anaerobes, and Mycoplasma

What formulations are available for Tylosin?

Injectable, feed additive, food additive

What is the trade name for Tylosin?

Tylan

What are the clinical indications for Tylosin?

BRD treatment, swine respiratory disease; liver abscess prevention in cattle; epiphora staining, IBD, post-anthelmintic diarrhea in dogs

What is a special consideration for Tylosin?

Co-selects for vancomycin resistance

What is the classification of Flofenicol?

Phenicol

What is the spectrum of Flofenicol?

Gm(+) and Gm(-)

What formulations are available for Flofenicol?

Injectable (NuFlor, ResFlor); water additive (Florivo)

What are the trade names for Flofenicol?

NuFlor, ResFlor (long-acting), Florivo

What are the clinical indications for Flofenicol?

BRD treatment; swine respiratory disease

What is a special consideration for Flofenicol?

ResFlor Gold is long-acting and contains flunixin

What is the classification of Chloramphenicol?

Phenicol

What is the spectrum of Chloramphenicol?

Gm(+) and Gm(-)

What formulation is available for Chloramphenicol?

Oral pill

What is the trade name for Chloramphenicol?

Generic

What are the clinical indications for Chloramphenicol?

Amphibian chytridiomycosis; koala chlamydiosis

What is a special consideration for Chloramphenicol?

NEVER use in food-producing animals

What is the classification of Clindamycin?

Lincosamide

What is the spectrum of Clindamycin?

All Gm(+) and Gm(-) anaerobes; Toxoplasma

What formulation is available for Clindamycin?

Oral pill

What is the trade name for Clindamycin?

Antirobe

What are the clinical indications for Clindamycin?

SA dental infections, osteomyelitis, anal sacculitis

What is a special consideration for Clindamycin?

Can cause pseudomembranous colitis; co-treat with metronidazole

What is the classification of Pirlimycin?

Lincosamide

What is the spectrum of Pirlimycin?

All Gm(+) and Gm(-) anaerobes

What formulation is available for Pirlimycin?

Intramammary

What is the trade name for Pirlimycin?

Pirsue

What are the clinical indications for Pirlimycin?

Gm(+) mastitis

What is a special consideration for Pirlimycin?

Shortest milk withhold of all intramammary preparations

What is the classification of Lincomycin?

Lincosamide

What is the spectrum of Lincomycin?

All Gm(+) and Gm(-) anaerobes

What formulation is available for Lincomycin?

Feed additive

What is the trade name for Lincomycin?

Lincomix

What are the clinical indications for Lincomycin?

Poultry and swine respiratory infections

What is the classification of Tiamulin?

Pleuromutilin

What is the spectrum of Tiamulin?

All Gm(+)

What formulations are available for Tiamulin?

Feed and water additive

What is the trade name for Tiamulin?

Tialin

What are the clinical indications for Tiamulin?

Poultry and swine respiratory infections

What is a special consideration for Tiamulin?

Be wary of swine dermatitis if pigs are overcrowded