mutations

What is the central dogma of molecular biology directly referring to ?

Unidirectional translation

A mutation occurs in a gene that prevents RNA polymerase from binding to the DNA. What is the most immediate impact on the cell?

The cell cannot synthesize RNA

The a- amanitin is a toxin which acts as an irreversible inhibitor of RNA polymerase. Which process will it inhibit

Transcription

Mutations are :

Permanent changes in the DNA sequence

Mutations in the DNA can impact _____ via transcription which can impact _____ via translation

RNA; proteins

Mutations are largely responsible for the tremendous _____ found amongst organisms

Diversity

What are point mutations?

Substitutions : change in 1 nucleotide

What is silent mutation?

No effect on amino acid sequences

If the codon changes from GCA to GGC : what time of mutation would occur

Silent mutation

How many changes occur in a missense mutation?

One change in amino acid

What type of mutation occurs when introduction of a pre-mature stop codon appears.

Nonsense mutation

Insertion and Deletion of nucleotides are what kind if mutations?

Frameshift mutations

Which of the following mutations occurring just after the start codon in the mRNA is likely to have the most serious effects on the polypeptide product ?

Deletion of one nucleotide

A single base substitution is LEAST likely to be deleterious when the change results in :

Replacement of a codon specifying an amino acid with a redundant codon specifying the same amino acid

What might be altered if the mRNA is present but the protein for an enzyme is absent in an organism?

Translation